CAJ | 학술논문

乳腺癌内分泌治疗最早可以追溯到1896年英国外科医生Beatson报道的采用卵巢切除术治疗绝经前复发转移乳腺癌.经过100多年的发展,内分泌治疗在乳腺癌的辅助治疗、复发转移后的解救治疗及新辅助内分泌治疗中都扮演着重要角色.从最初的单纯切除内分泌器官、他莫昔芬、药物性卵巢去势、第3代芳香化酶抑制剂4个方面对乳腺癌内分泌治疗的变迁进行综述分析,可以总结出不同时代内分泌治疗的特点,为探寻新的发展趋势提供借鉴.
유선암내분비치료최조가이추소도1896년영국외과의생Beatson보도적채용란소절제술치료절경전복발전이유선암.경과100다년적발전,내분비치료재유선암적보조치료、복발전이후적해구치료급신보조내분비치료중도분연착중요각색.종최초적단순절제내분비기관、타막석분、약물성란소거세、제3대방향화매억제제4개방면대유선암내분비치료적변천진행종술분석,가이총결출불동시대내분비치료적특점,위탐심신적발전추세제공차감.
The endocrine therapy for breast cancer could be traced back to the excision of the metastatic breast cancer by oophorectomy in a premenopausal women performed by Beatson in 1896.After the development of more than 100 years,endocrine therapy plays an important role in adjuvant therapy,the rescuing treatment of its recurrence due to metastasis,and the new adjuvant endocrine therapy for breast cancer.Through analyzing the changes in the 4 aspects of endocrine treatment of breast cancer,i.e.,the original simple excision of the endocrine organs,tamoxifen,drug-induced ovarian castration and the 3th generation aromatase inhibitor,the characteristics of different ages of endocrine therapy can be summarized,which would provide the reference for the new developmental trend of this therapy.