CAJ | 학술논문

目的：探讨多靶点治疗老年肾病综合征的临床疗效。方法我院2012-05~2014-05收治的63例老年肾病综合征患者随机分为多靶点治疗组和对照组。多靶点治疗组应用强的松、吗替麦考酚酯、他克莫司联合治疗，对照组应用强的松和环磷酰胺治疗。治疗3个月后，观察各治疗组的临床表现和尿液以及血液生化指标。结果治疗3个月后，多靶点组患者的治疗总有效率为96.88%(31/32)，明显高于对照组83.87%(26/31)(P<0.05)；多靶点组患者的尿蛋白定量、血肌酐、胆固醇以及血清白蛋白均较对照组明显改善(P<0.05)；多靶点组患者的复发率和不良反应发生率均明显低于对照组(P<0.05)。结论多靶点治疗老年肾病综合征的临床疗效显著。
목적：탐토다파점치료노년신병종합정적림상료효。방법아원2012-05~2014-05수치적63례노년신병종합정환자수궤분위다파점치료조화대조조。다파점치료조응용강적송、마체맥고분지、타극막사연합치료，대조조응용강적송화배린선알치료。치료3개월후，관찰각치료조적림상표현화뇨액이급혈액생화지표。결과치료3개월후，다파점조환자적치료총유효솔위96.88%(31/32)，명현고우대조조83.87%(26/31)(P<0.05)；다파점조환자적뇨단백정량、혈기항、담고순이급혈청백단백균교대조조명현개선(P<0.05)；다파점조환자적복발솔화불량반응발생솔균명현저우대조조(P<0.05)。결론다파점치료노년신병종합정적림상료효현저。
Objective To investigate the clinical efficacy of multi-targets therapy in treatment of elderly nephrotic syndrome. Methods Sixty-three elderly nephrotic syndrome patients in our hospital from May 2012 to May 2014 were randomly divided into the multi-target group and control group. Patients in multi-target group were treated with prednisone, mycophenolate mofetil( MMF) , tacrolimus, while patients in control group were treated with prednisone and cyclophosphamide. Clinical efficacy, urine and blood biochemical indexes were estimated after 3-month treatment. Results After 3-month treatment, the total effective rate in multi-target group was 96. 88%(31/32), significantly higher than in control group(83. 87%,P<0. 05). The urinary protein,serum creatinine,cholesterol and serum albumin were significantly improved in multi-target group compared with control group(P<0. 05). The recurrence rates and incidences of side effects were significantly lower in multi-target group than in control group(P<0. 05). Conclusion The clinical efficacy of multi-targets therapy in treatment of elderly nephrotic syndrome is significant.