CAJ | 학술논문

目的：观察微量泵持续注射硝普钠与多巴胺治疗顽固性心衰的临床疗效。方法：选择106例心功能Ⅲ～Ⅳ级顽固性心衰患者，采用微量泵持续泵入硝普钠和多巴胺进行顽固性心衰治疗，硝普钠起始剂量为6.25μg／min；同时采用另一微量泵持续泵入多巴胺，起始剂量为2 g/kg·min，直至血压下降至90～100 mm Hg；连续用药7 d，观察治疗后患者症状体征和心功能各参数的变化情况。结果：①106例顽固性心衰患者经硝普钠与多巴胺微泵治疗后，总有效率为85.85%(91/106)；②微量泵治疗后顽固性心衰患者的心率、血压、心胸比率、左室短轴缩短率、每搏输出量、每搏指数以及左室射血分数等参数较治疗前均有明显改善。结论：微量泵持续注射硝普钠与多巴胺治疗顽固性心衰的效果明显，不良反应较少，值得临床推广应用。
목적：관찰미량빙지속주사초보납여다파알치료완고성심쇠적림상료효。방법：선택106례심공능Ⅲ～Ⅳ급완고성심쇠환자，채용미량빙지속빙입초보납화다파알진행완고성심쇠치료，초보납기시제량위6.25μg／min；동시채용령일미량빙지속빙입다파알，기시제량위2 g/kg·min，직지혈압하강지90～100 mm Hg；련속용약7 d，관찰치료후환자증상체정화심공능각삼수적변화정황。결과：①106례완고성심쇠환자경초보납여다파알미빙치료후，총유효솔위85.85%(91/106)；②미량빙치료후완고성심쇠환자적심솔、혈압、심흉비솔、좌실단축축단솔、매박수출량、매박지수이급좌실사혈분수등삼수교치료전균유명현개선。결론：미량빙지속주사초보납여다파알치료완고성심쇠적효과명현，불량반응교소，치득림상추엄응용。
Objective: To observe the clinical effect of sodium nitroprusside and dopamine injected by micro pump for the treatment of refractory heart failure. Methods:One hundred and six cases of patients with refractory heart failure were chosen as the research object, which were cardiac functionⅢ~Ⅳlevel. All patients were treated with sodium nitroprusside and dopamine injected by micro pump. Starting dose of sodium nitroprusside was 6.25 μg/min. At same time pumping dopamine, starting dose of 2 g/kg·min, the dose was increased gradually until blood pressure dropped to 90~100 mm Hg, continuous 7~10 d, the signs and symptoms after treatment and parameters of cardiac function and adverse reactions were observed. Results: 1)In 106 cases of patients with refractory heart failure after treatment, the total effective rate 85.85%(91/106). 2)The heart rate, blood pressure, cardiothoracic ratio, left ventricular short axis reduced rate,cardiac output, each index of cardiac,indexes of left ventricular ejection fraction were improved significantly after treatment. Conclusion:The clinical effect for the treatment of refractory heart failure by using the micro pump injection of small doses of sodium nitroprusside combined dopamine would be obvious, have less adverse reactions, worthy of clinical popularization and application.