CAJ | 학술논문

目的：探讨沙培林（OK-432）和岩舒（复方苦参注射液）胸腔内给药对恶性胸腔积液中血管内皮生长因子（VEGF）及外周血TNF-α、IL-2的影响及其机制。方法88例恶性胸腔积液患者分为两组，对照组胸腔内注入沙培林，试验组胸腔内序贯注入沙培林和岩舒，对比疗效，检测胸水VEGF及外周血TNF-α、IL-2浓度。结果试验组治疗有效率为81.8%，高于对照组的61.3%（P＜0.05）；两组患者治疗后胸水VEGF浓度较治疗前降低（P＜0.05），外周血TNF-α、IL-2浓度较治疗前升高（P＜0.05）；两组治疗后对比，试验组胸水VEGF浓度较对照组降低（P＜0.05），外周血TNF-α、IL-2浓度较对照组升高（P＜0.05）。结论沙培林联合岩舒胸腔内用药能有效治疗恶性胸腔积液，降低胸水VEGF浓度及升高外周血TNF-α、IL-2浓度。
목적：탐토사배림（OK-432）화암서（복방고삼주사액）흉강내급약대악성흉강적액중혈관내피생장인자（VEGF）급외주혈TNF-α、IL-2적영향급기궤제。방법88례악성흉강적액환자분위량조，대조조흉강내주입사배림，시험조흉강내서관주입사배림화암서，대비료효，검측흉수VEGF급외주혈TNF-α、IL-2농도。결과시험조치료유효솔위81.8%，고우대조조적61.3%（P＜0.05）；량조환자치료후흉수VEGF농도교치료전강저（P＜0.05），외주혈TNF-α、IL-2농도교치료전승고（P＜0.05）；량조치료후대비，시험조흉수VEGF농도교대조조강저（P＜0.05），외주혈TNF-α、IL-2농도교대조조승고（P＜0.05）。결론사배림연합암서흉강내용약능유효치료악성흉강적액，강저흉수VEGF농도급승고외주혈TNF-α、IL-2농도。
Objective To explore the influence of VEGF, TNF-αand IL-2 levels of intrathoracic perfusion of OK-432 combined with compound Kushen injection in teatment of malignant pleural effusion. Methods 88 patients with malignant pleural effusion were randomly divided into 2 groups: control group treated with OK-432, test group treated with OK-432 com-bined with compound Kushen injection. The responses of pleural effusion were observed. The concentrations of VEGF in pleural effusion, TNF-αand IL-2 in peripheral blood were detected by ELISA. Results The effective rate in test group(81.8%) was higher than that in control group(61.3%), P<0.05. The concentrations of VEGF in pleural effusion reduced, TNF-αand IL-2 in peripheral blood significantly increased after the treatment in both groups (P<0.05). The concentration of VEGF in pleural effu-sion was lower in test group than control group (P<0.05), TNF-αand IL-2 in peripheral blood were significantly higher in test group than control group(P<0.05). Conclusion Treatment of malignant pleural effusion with intrathoracic OK-432 and com-pound Kushen injection has good efficacy. It can enhance the expression of TNF-αand interleukin-2, and lower VEGF level in pleural effusion.