CAJ | 학술논문

目的：探讨青年人后循环缺血（posterior circulation ischemic，PCI）的危险因素。方法收集2009年1月1日~2010年12月31日在首都医科大学宣武医院神经内科住院，年龄18~45岁且发病至就诊时间不超过14d的缺血性卒中患者。所有诊断均由头颅CT和/或MRI 证实，均进行了颅内外血管检查、心脏检查以及其他病因学检查。并排除因资料不全而难以给出病因学诊断及肺、肾、肝脏衰竭患者。将患者按性别、年龄分组，比较危险因素在不同组别中的差异，分析青年人后循环缺血的危险因素。结果高血压病、吸烟及饮酒史在不同年龄组中的分布有显著差异，具有统计学意义；这3种危险因素在36~45岁组中的发生率较18~25岁、26~35岁两组高。后循环缺血患者中男性与女性的年龄无显著性差异，高脂血症、吸烟史、饮酒史及高同型半胱氨酸血症在男性与女性中的分布有显著性差异，男性患者均高于女性患者。除高同型半胱氨酸外其他危险因素在青年人后循环缺血与前循环缺血的分布无明显差异；青年人前循环缺血患者高同型半胱氨酸血症的发生率高于后循环缺血患者。结论高脂血症、吸烟是青年人后循环梗死患者中较高血压、糖尿病更为常见的危险因素。
목적：탐토청년인후순배결혈（posterior circulation ischemic，PCI）적위험인소。방법수집2009년1월1일~2010년12월31일재수도의과대학선무의원신경내과주원，년령18~45세차발병지취진시간불초과14d적결혈성졸중환자。소유진단균유두로CT화/혹MRI 증실，균진행료로내외혈관검사、심장검사이급기타병인학검사。병배제인자료불전이난이급출병인학진단급폐、신、간장쇠갈환자。장환자안성별、년령분조，비교위험인소재불동조별중적차이，분석청년인후순배결혈적위험인소。결과고혈압병、흡연급음주사재불동년령조중적분포유현저차이，구유통계학의의；저3충위험인소재36~45세조중적발생솔교18~25세、26~35세량조고。후순배결혈환자중남성여녀성적년령무현저성차이，고지혈증、흡연사、음주사급고동형반광안산혈증재남성여녀성중적분포유현저성차이，남성환자균고우녀성환자。제고동형반광안산외기타위험인소재청년인후순배결혈여전순배결혈적분포무명현차이；청년인전순배결혈환자고동형반광안산혈증적발생솔고우후순배결혈환자。결론고지혈증、흡연시청년인후순배경사환자중교고혈압、당뇨병경위상견적위험인소。
Objective To explore the risk factors of the posterior circulation ischemic in the youth. Methods Col-lected the patients (18~45 years old) who were hospitalized in the Xuanwu Hospital of Capital Medical University because of a-cute ischemic stroke from Jan 1, 2009 to Dec 31, 2010, the prehospital delay time was less than 14 days. All the auxiliary ex-aminations including CT/MRI and those about intracranial and extracranial vascular and others about etiologies were completed. The patients with lung,liver or kidney failure and uncompleted auxiliary examination were excluded. The patients were grouped according to gender and ages. Analyzed the risk factors of the posterior circulation ischemic in the youth. Results There were significant differences in hypertension and the history of smoking and drinking between different ages. The patients with those risk factors between 36~45 years old were more than those between 18~25 years old and between 26~35 years old. There were no significant differences in the age between the male and the female patients of the PCI. There were significant differences in hyperlipidemia,history of smoking and drinking and hyperhomocysteinemia between the male and the female patients, those of the male patients were higher. The risk factors of ACI and PCI in the youth were similar except hyperhomocysteinemia. The inci-dence of hyperhomocysteinemia in ACI was higher than PCI. Conclusion The risk factors such as hyperlipidemia, smoking were more common than hypertension, diabetes in posterior circulation infarction patients.