CAJ | 학술논문

目的：研究分析肺癌脑转移立体定向放疗(stereotactic radiotherapy， SRT)后患者MRI变化情况及对近期疗效的评价情况。方法选择2010年1月至2013年12月在我院接受治疗的肺癌脑转移患者62例作为研究对象。所有患者均接受SRT治疗后，分析患者近期疗效及MRI变化情况，对比复发和可疑进展的时间情况。结果62例患者的120个病灶中，治疗后CR的病灶占比为25.00%，PR的病灶占比为15.00%，CR+PR有效率为40.00%。120个病灶中，经SRT治疗后复发28个，其中26个病灶挽救治疗后的体积增大，12个为结节状强化，14个为不均匀强化。可疑进展22个。病灶控制70个，其中12个体积较治疗前略微变大的病灶中，10个为光滑亦或是花环状的强化病灶，2个为不均匀强化并且没有明显瘤周水肿和占位效应的病灶。复发病灶的中位时间显著少于可疑进展的中位时间，差异有统计学意义（P＜0.05）。结论肺癌脑转移患者接受SRT治疗后的影像学表现较为多样，对于厚壁和结节样，以及不均匀强化等情况应在对症治疗、临床观察及其他类检查工具配合诊断的基础上确定SRT治疗效果。
목적：연구분석폐암뇌전이입체정향방료(stereotactic radiotherapy， SRT)후환자MRI변화정황급대근기료효적평개정황。방법선택2010년1월지2013년12월재아원접수치료적폐암뇌전이환자62례작위연구대상。소유환자균접수SRT치료후，분석환자근기료효급MRI변화정황，대비복발화가의진전적시간정황。결과62례환자적120개병조중，치료후CR적병조점비위25.00%，PR적병조점비위15.00%，CR+PR유효솔위40.00%。120개병조중，경SRT치료후복발28개，기중26개병조만구치료후적체적증대，12개위결절상강화，14개위불균균강화。가의진전22개。병조공제70개，기중12개체적교치료전략미변대적병조중，10개위광활역혹시화배상적강화병조，2개위불균균강화병차몰유명현류주수종화점위효응적병조。복발병조적중위시간현저소우가의진전적중위시간，차이유통계학의의（P＜0.05）。결론폐암뇌전이환자접수SRT치료후적영상학표현교위다양，대우후벽화결절양，이급불균균강화등정황응재대증치료、림상관찰급기타류검사공구배합진단적기출상학정SRT치료효과。
Objective To study evaluation analysis of lung cancer with brain metastasis patients after stereotactic radiotherapy MRI change condition and for short-term effect. Methods 62 cases of patients were chosen as the research object from January 2010 to December 2013 in our hospital to accept the treatment of brain metastases of lung cancer. All patients were given with SRT, after treatment analysis of patients with recent curative effect and changes of MRI, time and suspicious recurrence progress of contrast.Results 62 cases of patients with 120 lesions, after treatment of CR lesions accounted for 25%, PR lesions accounted for 15%, CR+PR efficiency was 40%. 120 lesions, after the treatment of SRT recurrence in 28, of which 26 lesions after salvage treatment volume increased, 12 was as nodular enhancement, 14 was heterogeneous enhancement. Suspicious progress was 22. Focus control 70, of which 12 volume than before treatment slightly larger lesions, 10 smooth or flower ring enhancing lesions, 2 heterogeneous enhancement and no obvious peritumoral edema and mass effect of the lesions. The median time to relapse at a median time of lesions was significantly less suspicious progression; the difference was statistically significant (P<0.05).Conclusion The patients of brain metastases from lung cancer treated with SRT imaging findings are various, for thick wall and nodular, and inhomogeneous enhancement etc. shall determine the therapy effect of SRT therapy, the clinical observation in symptomatic and basis for other classes with the diagnosis of inspection tools.