中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2015年
3期
140-147
,共8页
林瑞腾%程大川%张朝凯%张泳
林瑞騰%程大川%張朝凱%張泳
림서등%정대천%장조개%장영
模型%圆锥角膜%眼科设备%紫外线%角膜胶原交联
模型%圓錐角膜%眼科設備%紫外線%角膜膠原交聯
모형%원추각막%안과설비%자외선%각막효원교련
Modeling%Keratoconus%Ophthalmic devices%UV light%Corneal collagen cross-linking
目的 探讨紫外线引发角膜交联光动力学的关键问题,并以实验数据确认紫外线在核黄素内的吸收动力学理论.方法 耦合动力学方程的数值求解和分析公式推导出3个重要的参数:安全深度(z*),安全剂量(E*)和交联时间(T*).经由对时间函数的核黄素吸收系数实验测量,核黄素的动态频谱显示光敏剂随时间的耗竭.角膜交联光动力是由7个关键参数决定:核黄素(B2)的消光系数,浓度,光敏剂穿透深度,紫外线的强度和剂量,照射时间以及角膜厚度.结果 核黄素浓度范围为0.1％-0.2％,穿透深度范围为0.02～0.04 cm,安全剂量范围为2.3～8.2 J/cm2.我们的数学模式显示,较高的紫外线强度和消光系数导致较短的表面交联时间,而角膜厚度大的交联时间也增加.安全深度为消光系数和光敏剂浓度的反比函数.结论 基于我们的新的发现,角膜胶原交联术的动态安全参数包括安全深度,安全剂量,交联时间,和安全光敏剂浓度,我们提出一个新的交联临床规范.
目的 探討紫外線引髮角膜交聯光動力學的關鍵問題,併以實驗數據確認紫外線在覈黃素內的吸收動力學理論.方法 耦閤動力學方程的數值求解和分析公式推導齣3箇重要的參數:安全深度(z*),安全劑量(E*)和交聯時間(T*).經由對時間函數的覈黃素吸收繫數實驗測量,覈黃素的動態頻譜顯示光敏劑隨時間的耗竭.角膜交聯光動力是由7箇關鍵參數決定:覈黃素(B2)的消光繫數,濃度,光敏劑穿透深度,紫外線的彊度和劑量,照射時間以及角膜厚度.結果 覈黃素濃度範圍為0.1％-0.2％,穿透深度範圍為0.02～0.04 cm,安全劑量範圍為2.3～8.2 J/cm2.我們的數學模式顯示,較高的紫外線彊度和消光繫數導緻較短的錶麵交聯時間,而角膜厚度大的交聯時間也增加.安全深度為消光繫數和光敏劑濃度的反比函數.結論 基于我們的新的髮現,角膜膠原交聯術的動態安全參數包括安全深度,安全劑量,交聯時間,和安全光敏劑濃度,我們提齣一箇新的交聯臨床規範.
목적 탐토자외선인발각막교련광동역학적관건문제,병이실험수거학인자외선재핵황소내적흡수동역학이론.방법 우합동역학방정적수치구해화분석공식추도출3개중요적삼수:안전심도(z*),안전제량(E*)화교련시간(T*).경유대시간함수적핵황소흡수계수실험측량,핵황소적동태빈보현시광민제수시간적모갈.각막교련광동력시유7개관건삼수결정:핵황소(B2)적소광계수,농도,광민제천투심도,자외선적강도화제량,조사시간이급각막후도.결과 핵황소농도범위위0.1％-0.2％,천투심도범위위0.02～0.04 cm,안전제량범위위2.3～8.2 J/cm2.아문적수학모식현시,교고적자외선강도화소광계수도치교단적표면교련시간,이각막후도대적교련시간야증가.안전심도위소광계수화광민제농도적반비함수.결론 기우아문적신적발현,각막효원교련술적동태안전삼수포괄안전심도,안전제량,교련시간,화안전광민제농도,아문제출일개신적교련림상규범.
Objective To discuss the critical issues of the dynamics of UV-light-photoinitiated cross-linking in corneal collagen (CXL) and to confirm the dynamics of riboflavin (vitamin-B2) absorption under UV light.Methods Coupled dynamic equations are numerically solved and analytic formulas are derived for three critical parameters:the safe depth (z*),the safe dose (E*) and the cross-linking time (t*).Time-dependent absorption of UV light due to the depletion of the initiator is measured and shown by a dynamic spectrum of riboflavin.The critical issues of CXL are explored by seven parameters:the extinction coefficient,concentration,the penetration depth of the riboflavin,the UV light intensity and dose,irradiation duration,and corneal thickness.Results The safe dose (E*) has a wide range from 2.3 to 8.2 (J/cm2) for riboflavin concentrations of 0.1％ to 0.2％ and penetration depths of 0.02 to 0.04 cm.It is shown by mathematical modeling that a higher light intensity and extinction coefficient lead to shorter t* for a given cross-linking depth,while t* increases with corneal thickness (z*).The safety depth decreases as a function of the extinction coefficient and initiator concentration.Conclusion A new cross-linking protocol is suggested based on new findings,which include the safe depth (z*),the safe dose (E*),the cross-linking time (T*),and the safe riboflavin concentration.
