CAJ | 학술논문

目的：探讨重组人干扰素α-2b联合子宫颈电热圈环切术（ LEEP）治疗有症状的宫颈柱状上皮异位的临床疗效。方法：对我院2012年4月~2014年4月行LEEP术治疗的68例有症状的宫颈柱状上皮异位患者的病历资料进行回顾性分析，其中对照组30例单纯行LEEP术治疗，并于术后常规口服抗菌药5 d预防感染；观察组38例在对照组基础上给予重组人干扰素α-2b栓10万IU阴道放置，隔日1次，10 d为1个疗程，每月于月经干净后使用2个疗程，6个疗程后观察两组患者临床疗效、阴道出血时间、阴道排液持续时间、创面愈合时间及治疗前后HPV持续感染率。结果：对照组治愈率66.67%，观察组治愈率为92.11%，差异有统计学意义（P<0.05）；对照组创面愈合19例（63.33%），观察组创面愈合32例（84.21%），差异有统计学意义（ P<0.05），且观察组阴道出血时间、阴道排液持续时间、创面愈合时间均显著短于对照组（ P<0.05）。治疗后，对照组HPV持续感染率为16.67%；治疗组HPV持续感染率为0，差异有统计学意义（ P<0.05）。两组患者治疗过程中均未见明显药品不良反应。结论：重组人干扰素α-2b联合LEEP术治疗有症状的宫颈柱状上皮异位安全有效，可有效缩短创面愈合时间、阴道出血时间、阴道排液持续时间，值得在临床上推广使用。
목적：탐토중조인간우소α-2b연합자궁경전열권배절술（ LEEP）치료유증상적궁경주상상피이위적림상료효。방법：대아원2012년4월~2014년4월행LEEP술치료적68례유증상적궁경주상상피이위환자적병력자료진행회고성분석，기중대조조30례단순행LEEP술치료，병우술후상규구복항균약5 d예방감염；관찰조38례재대조조기출상급여중조인간우소α-2b전10만IU음도방치，격일1차，10 d위1개료정，매월우월경간정후사용2개료정，6개료정후관찰량조환자림상료효、음도출혈시간、음도배액지속시간、창면유합시간급치료전후HPV지속감염솔。결과：대조조치유솔66.67%，관찰조치유솔위92.11%，차이유통계학의의（P<0.05）；대조조창면유합19례（63.33%），관찰조창면유합32례（84.21%），차이유통계학의의（ P<0.05），차관찰조음도출혈시간、음도배액지속시간、창면유합시간균현저단우대조조（ P<0.05）。치료후，대조조HPV지속감염솔위16.67%；치료조HPV지속감염솔위0，차이유통계학의의（ P<0.05）。량조환자치료과정중균미견명현약품불량반응。결론：중조인간우소α-2b연합LEEP술치료유증상적궁경주상상피이위안전유효，가유효축단창면유합시간、음도출혈시간、음도배액지속시간，치득재림상상추엄사용。
Objective:To investigate the clinical efficacy of recombinant human interferon alpha -2b combined with Loop electro-sugical excision procedure( LEEP)in the treatment of cervical ectopic columnar epithelium with chronic cervicitis. Methods:The med-ical records of 68 cases of cervical ectopic columnar epithelium with chronic cervicitis in our hospital from April 2012 to April 2014 treated with LEEP were analyzed retrospectively. The control group(30 cases)was treated with LEEP combined with 5-day postopera-tive oral administration of antibiotics to prevent infection,and the treatment group(38 cases)was given recombinant human interferon alpha -2b through vagina additionally,every other day for 20 days every month after menstrua. After 6 courses of treatment,the clinical efficacy,vaginal bleeding time,vaginal discharge duration,wound healing time and HPV persistent infection were compared between the two groups. Results:The cure rate of the control group was 66. 67%,while that of the treatment group was 92. 11%,and the difference was significant(P<0. 05). Totally 19 cases in the control group were with wound healing(accounted for 63. 33%),while that in the treatment group was 32 cases(accounted for 84. 21%),the difference was significant(P<0. 05). And the vaginal bleeding time,vaginal discharge duration,and wound healing time of the treatment group were all significantly shorter than those of the control group(P<0. 05). After the treatment,the HPV persistent infection rate in the control group was 16. 67%,while that in the treatment group was 0%,and the difference was statistically significant(P<0. 05). The two groups during the treatment process had no obvious adverse reactions,indicating high drug safety. Conclusion:Recombinant human interferon alpha-2b combined with LEEP in the treat-ment of cervical ectopic columnar epithelium is safe and effective,which can effectively shorten the wound healing time,vaginal bleed-ing time and vaginal discharge duration,and is worthy of promotion in clinics.