中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
4期
598-599
,共2页
环吡酮胺阴道栓%氟康唑%特比萘芬阴道泡腾片%外阴阴道假丝酵母菌
環吡酮胺陰道栓%氟康唑%特比萘芬陰道泡騰片%外陰陰道假絲酵母菌
배필동알음도전%불강서%특비내분음도포등편%외음음도가사효모균
Ciclopirox vaginal suppositories%Fluconazole%Terbinafine vaginal effervescent tablets%Vulvovaginal candidiasis
目的：观察环吡酮胺阴道栓联合氟康唑治疗外阴阴道假丝酵母菌的疗效观察。方法：74例外阴阴道假丝酵母菌（ VVC）感染患者随机分为两组各37例。对照组给予口服氟康唑联合阴道内放置盐酸特比萘芬阴道泡腾片，观察组给予口服氟康唑联合环吡酮胺阴道栓治疗，观察对比两组近期（7 d）、远期（1、3个月）的临床疗效及用药安全性。结果：治疗7 d后，两组临床总有效率差异无统计学意义（ P>0.05）；1个月后随访，两组复发率比较，差异无统计学意义（ P>0.05），3个月后随访，观察组复发率为2.7%，明显低于对照组的22.2%（P<0.05）。两组均未发生严重药物不良反应。结论：口服氟康唑联合环吡酮胺阴道栓治疗外阴阴道假丝酵母菌疗效确切，可明显降低复发率，且用药安全，无严重不良反应。
目的：觀察環吡酮胺陰道栓聯閤氟康唑治療外陰陰道假絲酵母菌的療效觀察。方法：74例外陰陰道假絲酵母菌（ VVC）感染患者隨機分為兩組各37例。對照組給予口服氟康唑聯閤陰道內放置鹽痠特比萘芬陰道泡騰片，觀察組給予口服氟康唑聯閤環吡酮胺陰道栓治療，觀察對比兩組近期（7 d）、遠期（1、3箇月）的臨床療效及用藥安全性。結果：治療7 d後，兩組臨床總有效率差異無統計學意義（ P>0.05）；1箇月後隨訪，兩組複髮率比較，差異無統計學意義（ P>0.05），3箇月後隨訪，觀察組複髮率為2.7%，明顯低于對照組的22.2%（P<0.05）。兩組均未髮生嚴重藥物不良反應。結論：口服氟康唑聯閤環吡酮胺陰道栓治療外陰陰道假絲酵母菌療效確切，可明顯降低複髮率，且用藥安全，無嚴重不良反應。
목적：관찰배필동알음도전연합불강서치료외음음도가사효모균적료효관찰。방법：74예외음음도가사효모균（ VVC）감염환자수궤분위량조각37례。대조조급여구복불강서연합음도내방치염산특비내분음도포등편，관찰조급여구복불강서연합배필동알음도전치료，관찰대비량조근기（7 d）、원기（1、3개월）적림상료효급용약안전성。결과：치료7 d후，량조림상총유효솔차이무통계학의의（ P>0.05）；1개월후수방，량조복발솔비교，차이무통계학의의（ P>0.05），3개월후수방，관찰조복발솔위2.7%，명현저우대조조적22.2%（P<0.05）。량조균미발생엄중약물불량반응。결론：구복불강서연합배필동알음도전치료외음음도가사효모균료효학절，가명현강저복발솔，차용약안전，무엄중불량반응。
Objective:To explore the efficacy of ciclopirox olamine vaginal suppositories combined with fluconazole in the treat-ment of vulvovaginal candidasis. Methods:Totally 74 cases of vulvovaginal candidasis( VVC)infection were randomly divided into two groups with 37 ones in each. The control group orally received fluconazole combined with terbinafine hydrochloride vaginal effervescent tablets,and the observation group orally received fluconazole combined with ciclopirox olamine vaginal suppositories. The recent(7 days)and long-term(1 and 3 months)clinical curative effects and the drug safety in the two groups were observed and compared. Re-sults:after the 7-day treatment,the total clinical effective rate of the two groups showed no significant difference(P>0. 05);after the 1-month follow-up,the recurrence rate of the two groups had no significant difference(P>0. 05);after the 3-month follow-up,the re-currence rate of the observation group(2. 7%)was significantly lower than that of the control group(22. 2%,P<0. 05). The two groups showed no serious adverse drug reactions. Conclusion:Fluconazole combined with ciclopirox olamine vaginal suppositories in the treatment of vulvovaginal candidasis exhibits promising curative effect and low recurrence rate without serious adverse reactions.
