中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
4期
616-617,643
,共3页
舍曲林片%糖尿病%抑郁
捨麯林片%糖尿病%抑鬱
사곡림편%당뇨병%억욱
Sertraline%Diabetes%Depression
目的：探讨糖尿病合并抑郁患者口服舍曲林片的疗效与安全性。方法：74例糖尿病合并抑郁患者随机分为2组各37例，两组均予二甲双胍片500 mg，po，tid。观察组在此基础上加用舍曲林片50~100 mg，po，qd。两组疗程均为8周。对比两组患者治疗前后的糖代谢指标、抑郁自评量表（ SDS）、糖尿病生命质量量表（ DMQLS）评分的变化情况。结果：治疗8周后，两组患者血糖、SDS评分和DMQLS评分均较治疗前明显改善（ P<0.05）；且观察组FBG、2hPG、HbAlc水平及SDS评分明显低于对照组（P<0.05），DMQLS疾病、生理、心理、社会、满意度维度评分明显高于对照组（P<0.05）。两组不良反应发生率比较，差异无统计学意义（ P>0.05）。结论：口服舍曲林片可改善糖尿病合并抑郁患者抑郁症状，提高血糖控制效果及生活质量。
目的：探討糖尿病閤併抑鬱患者口服捨麯林片的療效與安全性。方法：74例糖尿病閤併抑鬱患者隨機分為2組各37例，兩組均予二甲雙胍片500 mg，po，tid。觀察組在此基礎上加用捨麯林片50~100 mg，po，qd。兩組療程均為8週。對比兩組患者治療前後的糖代謝指標、抑鬱自評量錶（ SDS）、糖尿病生命質量量錶（ DMQLS）評分的變化情況。結果：治療8週後，兩組患者血糖、SDS評分和DMQLS評分均較治療前明顯改善（ P<0.05）；且觀察組FBG、2hPG、HbAlc水平及SDS評分明顯低于對照組（P<0.05），DMQLS疾病、生理、心理、社會、滿意度維度評分明顯高于對照組（P<0.05）。兩組不良反應髮生率比較，差異無統計學意義（ P>0.05）。結論：口服捨麯林片可改善糖尿病閤併抑鬱患者抑鬱癥狀，提高血糖控製效果及生活質量。
목적：탐토당뇨병합병억욱환자구복사곡림편적료효여안전성。방법：74례당뇨병합병억욱환자수궤분위2조각37례，량조균여이갑쌍고편500 mg，po，tid。관찰조재차기출상가용사곡림편50~100 mg，po，qd。량조료정균위8주。대비량조환자치료전후적당대사지표、억욱자평량표（ SDS）、당뇨병생명질량량표（ DMQLS）평분적변화정황。결과：치료8주후，량조환자혈당、SDS평분화DMQLS평분균교치료전명현개선（ P<0.05）；차관찰조FBG、2hPG、HbAlc수평급SDS평분명현저우대조조（P<0.05），DMQLS질병、생리、심리、사회、만의도유도평분명현고우대조조（P<0.05）。량조불량반응발생솔비교，차이무통계학의의（ P>0.05）。결론：구복사곡림편가개선당뇨병합병억욱환자억욱증상，제고혈당공제효과급생활질량。
Objective:To investigate the effect and safety of sertraline tablets with oral administration in the diabetes patients com-plicated with depression. Methods:Totally 74 diabetes patients complicated with depression were randomly divided into 2 groups with 37 ones in each. All the patients were orally given dimethyldiguanide 500 mg,tid,and the observation group was given sertraline tablets additionally,50-100 mg,qd. The treatment course was 8 weeks. The changes of sugar metabolism and the scores of self-rating depres-sion scale( SDS)and quality of life scale( DMQLS)in the two groups were compared. Results:After the 8-week treatment,the blood sugar,SDS scores and DMQLS scores in the two groups were significantly improved when compared with those before the treatment( P<0. 05). The levels of FBG,2hPG and HbAlc and SDS scores in the observation group were significantly lower than those in the con-trol group(P<0. 05),while the scores of DMQLS disease,psychology,society and satisfaction dimension were significantly higher in the observation group(P<0. 05). The incidence of adverse reactions showed no statistically significant difference between the two groups(P>0. 05). Conclusion:Sertraline tablets can improve the depression of diabetes patients and enhance the blood sugar control and quality of life.
