中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
4期
611-613
,共3页
铝碳酸镁%奥美拉唑%胃溃疡%胃出血%疗效
鋁碳痠鎂%奧美拉唑%胃潰瘍%胃齣血%療效
려탄산미%오미랍서%위궤양%위출혈%료효
Hydrotalcite%Omeprazole%Gastric ulcer%Gastric bleeding%Curative effect
目的：探讨铝碳酸镁联合奥美拉唑治疗胃溃疡合并胃出血的疗效。方法：76例胃溃疡合并胃出血患者随机分成两组，对照组（32例）单独使用奥美拉唑治疗，观察组（44例）联合奥美拉唑、铝碳酸镁治疗，比较两组的治疗效果。结果：观察组治疗总有效率100.0%，对照组总有效率87.5%，两组差异有统计学意义（P<0.05）；观察组治疗后症状综合评分（4.2±1.2）分，对照组（6.2±1.4）分，差异有统计学意义（P<0.01）；观察组腹痛、腹胀、嗳气缓解时间略短于对照组（P>0.05），呕血和便血缓解时间明显短于对照组（P<0.05）；3个月后观察组再出血发生率略少于对照组（P>0.05）。两组药品不良反应发生率差异无统计学意义（ P>0.05）。结论：铝碳酸镁联合奥美拉唑治疗胃溃疡合并胃出血的疗效明显，安全性良好。
目的：探討鋁碳痠鎂聯閤奧美拉唑治療胃潰瘍閤併胃齣血的療效。方法：76例胃潰瘍閤併胃齣血患者隨機分成兩組，對照組（32例）單獨使用奧美拉唑治療，觀察組（44例）聯閤奧美拉唑、鋁碳痠鎂治療，比較兩組的治療效果。結果：觀察組治療總有效率100.0%，對照組總有效率87.5%，兩組差異有統計學意義（P<0.05）；觀察組治療後癥狀綜閤評分（4.2±1.2）分，對照組（6.2±1.4）分，差異有統計學意義（P<0.01）；觀察組腹痛、腹脹、噯氣緩解時間略短于對照組（P>0.05），嘔血和便血緩解時間明顯短于對照組（P<0.05）；3箇月後觀察組再齣血髮生率略少于對照組（P>0.05）。兩組藥品不良反應髮生率差異無統計學意義（ P>0.05）。結論：鋁碳痠鎂聯閤奧美拉唑治療胃潰瘍閤併胃齣血的療效明顯，安全性良好。
목적：탐토려탄산미연합오미랍서치료위궤양합병위출혈적료효。방법：76례위궤양합병위출혈환자수궤분성량조，대조조（32례）단독사용오미랍서치료，관찰조（44례）연합오미랍서、려탄산미치료，비교량조적치료효과。결과：관찰조치료총유효솔100.0%，대조조총유효솔87.5%，량조차이유통계학의의（P<0.05）；관찰조치료후증상종합평분（4.2±1.2）분，대조조（6.2±1.4）분，차이유통계학의의（P<0.01）；관찰조복통、복창、애기완해시간략단우대조조（P>0.05），구혈화편혈완해시간명현단우대조조（P<0.05）；3개월후관찰조재출혈발생솔략소우대조조（P>0.05）。량조약품불량반응발생솔차이무통계학의의（ P>0.05）。결론：려탄산미연합오미랍서치료위궤양합병위출혈적료효명현，안전성량호。
Objective:To study the curative effect of hydrotalcite combined with omeprazole in the treatment of gastric ulcer with gastric bleeding. Methods:Seventy-six patients with gastric ulcer and bleeding in the stomach were selected and randomly divided into two groups. Thirty-two patients in the control group were treated with omeprazole alone while 44 patients in the observation group were treated with hydrotalcite combined with omeprazole. The therapeutic effects were compared between the two groups. Results:The total effective rate in the observation group was 100% while that was 87. 5% in the control group,and the difference between the two groups was statistically significant(P<0. 05). The comprehensive score of symptoms of the patients in the observation group was(4. 2 ± 1. 2)while that was(6. 2 ± 1. 4)in the control group,and the difference was significant(P<0. 01). The abdominal pain,abdominal distention and belching remission time in the observation group were slightly shorter than those in the control group(P<0. 05)and the time of hematemesis and hemafecia remission was significantly shorter than that in the control group(P<0. 05). After the 3-month treatment,the re-bleeding rate in the observation group was 6. 82%,which was slightly better than that in the control group,and the difference had no statistical significance(P<0. 05). The incidence of adverse reactions in the observation group was 9. 09% while that was 6. 25% in the control group,and there was no significant difference between the two groups(P>0. 05). Conclusion:Hydro-talcite combined with omeprazole in the treatment of gastric ulcer with gastric bleeding is effective and safe.
