CAJ | 학술논문

目的：分析临床药师参与狼疮性肾炎并发社区获得性肺炎患者抗感染用药监护。方法：对1例狼疮性肾炎并发社区获得性肺炎（重症）患者进行全程药学监护，协助医师制定抗感染药物治疗方案，并随病情变化作修正或调整。结果：莫西沙星和哌拉西林钠/他唑巴坦钠的联合用药，使患者的肺部感染得到及时有效控制，避免了潜在狼疮性肾炎复发或加重的危险。结论：特殊人群抗菌药物的选择，不仅要考虑抗菌谱、抗菌活性，还应结合患者的个体特征和药动学特性来做综合选择，可提高患者用药的安全性和有效性。
목적：분석림상약사삼여랑창성신염병발사구획득성폐염환자항감염용약감호。방법：대1례랑창성신염병발사구획득성폐염（중증）환자진행전정약학감호，협조의사제정항감염약물치료방안，병수병정변화작수정혹조정。결과：막서사성화고랍서림납/타서파탄납적연합용약，사환자적폐부감염득도급시유효공제，피면료잠재랑창성신염복발혹가중적위험。결론：특수인군항균약물적선택，불부요고필항균보、항균활성，환응결합환자적개체특정화약동학특성래주종합선택，가제고환자용약적안전성화유효성。
Objective:To explore the value of clinical pharmacists in the anti-infection practice for a patient with lupus nephritis complicated with community-acquired pneumonia(severe). Methods:Clinical pharmacists carried out medication monitoring in the entire treatment process of a patient with lupus nephritis complicated with community-acquired pneumonia( severe)in the clinical front line. Depending on the pharmaceutical knowledge,clinical pharmacists assisted physicians to make out the optimal medication and ad-justed the medication according to the patient′s conditions. Results:Moxifloxacin and piperacillin sodium /tazobactam sodium could ef-fectively control the severe pulmonary infection of the patient with lupus nephritis and avoid the potential risk of recurrence or aggrava-tion of lupus nephritis. Conclusion:The choice of antimicrobial agents for the special populations should consider not only the antibac-terial spectrum and antibacterial activity,but also the individual characteristics of patients and pharmacokinetics of drugs in order to im-prove the safety and effectiveness of medication.