CAJ | 학술논문

目的：应用血管回声跟踪（ET）和瞬时波强（WI）2种超声技术探讨2型糖尿病患者心血管功能状态。方法将136例男性退休干部按是否患糖尿病分为糖尿病组（n＝54）和对照组（n＝72）。均进行血糖血脂测定和超声检查，ET技术测量僵硬度指数（β）、弹性模量（Ep）、顺应性（Ac）、膨大指数（AI）、单点脉搏波传导速度（PWVβ），WI技术测量收缩早期正向波峰值（W1）、收缩晚期正向波（W2）、负向波面积（NA）、心电图R波顶点至W1顶点时间（R-1st）、W1顶点至W2顶点时间（1st～2nd）。结果（1）2组间年龄、血压、体质量指数、左室射血分数和血脂差异均无统计学意义，糖尿病组血糖[（8．28±1．19） mmol／L]高于对照组[（6．14±0．60）mmol／L]，差异有统计学意义（P＜0．01）。（2）2组间β、Ep、Ac、AI、PWVβ差异无统计学意义。（3）糖尿病组W1、W2[（10．08±6．76）×10－3、（1．35±1．57）×10－3 mmHg· m· s－3]显著低于对照组[（13．09±11．17）×10－3、（2．04±1．19）×10－3 mmHg· m· s－3]，差异有统计学意义（均P＜0．05），2组间NA、R-1st与1st ～2nd差异无统计学意义。结论 ET参数表明糖尿病患者颈动脉弹性未出现下降，而WI技术可早期检测到糖尿病患者亚临床期心肌病变。
목적：응용혈관회성근종（ET）화순시파강（WI）2충초성기술탐토2형당뇨병환자심혈관공능상태。방법장136례남성퇴휴간부안시부환당뇨병분위당뇨병조（n＝54）화대조조（n＝72）。균진행혈당혈지측정화초성검사，ET기술측량강경도지수（β）、탄성모량（Ep）、순응성（Ac）、팽대지수（AI）、단점맥박파전도속도（PWVβ），WI기술측량수축조기정향파봉치（W1）、수축만기정향파（W2）、부향파면적（NA）、심전도R파정점지W1정점시간（R-1st）、W1정점지W2정점시간（1st～2nd）。결과（1）2조간년령、혈압、체질량지수、좌실사혈분수화혈지차이균무통계학의의，당뇨병조혈당[（8．28±1．19） mmol／L]고우대조조[（6．14±0．60）mmol／L]，차이유통계학의의（P＜0．01）。（2）2조간β、Ep、Ac、AI、PWVβ차이무통계학의의。（3）당뇨병조W1、W2[（10．08±6．76）×10－3、（1．35±1．57）×10－3 mmHg· m· s－3]현저저우대조조[（13．09±11．17）×10－3、（2．04±1．19）×10－3 mmHg· m· s－3]，차이유통계학의의（균P＜0．05），2조간NA、R-1st여1st ～2nd차이무통계학의의。결론 ET삼수표명당뇨병환자경동맥탄성미출현하강，이WI기술가조기검측도당뇨병환자아림상기심기병변。
Objective To explore the cardiovascular function in type 2 diabetic patients by echo tracking (ET) and instanta-neous wave intensity ( WI) .Methods One hundred and thirty-six retired male veterans were divided into the diabetic group ( n=54) and the control group (n=72), by depending upon whether they had diabetes mellitus .They all received blood lipid detection and ul-trasonography .Echo tracking was used to measure stiffness index (β) , Peterson′s pressure modulus ( Ep) , arterial compliance ( AC) , augmentation index (AI), pulse wave velocity derived from β(PWVβ) on ET curve.Wave intensity was employed to detect accelera-ting wave intensity (W1), decelerating wave intensity (W2) and negative area (NA) on WI curve, as well as the interval between the maximum of R wave and that of W1, and the interval between the maximum of W1 and that of W2(1st-2nd).Results (1) No statisti-cal differences could be seen in age , blood pressure , body mass index , left ventricular ejection fraction and blood lipid , when compari-sons were made between the 2 groups.Blood glucose level [(8.28 ±1.19)mmol/L] in the diabetic group was higher than that [(6.14 ±0.60) mmol/L] of the control group, all with statistical significance(p<0.05).(2) No statistical differences could be noticed in the levels of β, Ep, Ac, AI and PWVβ, when comparisons were made between the 2 groups.(3) W1 and W2 [(10.08 ±6.76) × 103,(1.35 ±1.57) ×103 mmHg· m· s-3] for the diabetic group were significantly lower than those [(13.09 ±11.17) ×103,(2.04 ±1.19) ×103 mmHg· m· s-3] of the control group, all with statistical significance(P<0.05).No statistical differences could be seen in NA, R-1st and 1st-2nd, when comparisons were made between the two groups .Conclusion ET index indicated that carotid e-lasticity in type 2 diabetic patients was not decreased , but W1 could detect early subclinical myocardial lesion in diabetic patients .