CAJ | 학술논문

本文主要介绍了Neurod1在内耳感觉神经元及毛细胞发育中的相关研究。Neurod1是bHLH转录因子家族中的重要一员，它能促进感觉神经元前体细胞分化为成熟感觉神经元细胞。在内耳中，Neurod1主要表达于感觉神经元细胞，部分感觉上皮也有表达。Neurod1基因条件性敲除小鼠可出现听力及平衡障碍，其内耳感觉神经元细胞大量缺失，同时内耳中的传入及传出神经也存在缺陷。Neurod1基因敲除小鼠螺旋神经节中还可出现异位毛细胞的生长。在内耳发育过程中，Neurod1基因与多种基因相互调控，协同促进内耳发育成熟。如Neurog1、Atoh1、Sox2、Nhlh1等。
본문주요개소료Neurod1재내이감각신경원급모세포발육중적상관연구。Neurod1시bHLH전록인자가족중적중요일원，타능촉진감각신경원전체세포분화위성숙감각신경원세포。재내이중，Neurod1주요표체우감각신경원세포，부분감각상피야유표체。Neurod1기인조건성고제소서가출현은력급평형장애，기내이감각신경원세포대량결실，동시내이중적전입급전출신경야존재결함。Neurod1기인고제소서라선신경절중환가출현이위모세포적생장。재내이발육과정중，Neurod1기인여다충기인상호조공，협동촉진내이발육성숙。여Neurog1、Atoh1、Sox2、Nhlh1등。
This article focuses on the research on Neurod1’s roles in the development of sensory neurons and hair cells in the inner ear. Neurod1 is an important member of the bHLH transcription factors family. It promotes differentiation of neuro?nal precursor cells into neurons. In the inner ear, Neurod1 is mainly expressed on sensory neurons and part of the sensory epi?thelium. Conditional Neurod1 knockout mice exhibit hearing and balance disorders, with significant loss of sensory neurons in the inner ear and defects of both afferent and efferent nerves. Ectopic hair cells can also appear in the spiral ganglion in condi?tional Neurod1 knockout mice. In the process of inner ear development, Neurod1 interacts with multiple genes including Neu?rog1, Atoh1, Sox2 and Nhlh1.