CAJ | 학술논문

眼用新剂型在提高眼部生物利用度同时，也引入了大量以表面活性剂、高分子聚合物、阳离子材料等具有刺激性的物质。因此，在保证眼部制剂有效性的同时，其安全性也越来越受到关注。由于体外实验缺乏相关的酶系和组织结构的整体反应，其结果外推至动物实验的合理性和关联性也有待于进一步研究证明。本文综述了常用的体内（眨眼、组织病理切片、Draize评分、共聚焦显微镜法等）眼部刺激性实验方法，并对这些方法进行了评估和分析。
안용신제형재제고안부생물이용도동시，야인입료대량이표면활성제、고분자취합물、양리자재료등구유자격성적물질。인차，재보증안부제제유효성적동시，기안전성야월래월수도관주。유우체외실험결핍상관적매계화조직결구적정체반응，기결과외추지동물실험적합이성화관련성야유대우진일보연구증명。본문종술료상용적체내（잡안、조직병리절편、Draize평분、공취초현미경법등）안부자격성실험방법，병대저사방법진행료평고화분석。
Various new ophthalmic formulations have been prepared to enhance ocular bioavailability,while lots of irritant sub-stances are applied,including surfactants,polymers and other cationic materials. Therefore,safety of the preparations has been paid more and more attention besides the efficacy. Since in vitro experiments lack of associated enzymes and integral reaction of organiza-tion,the reasonability and correlation of the results extrapolated to the animal experiments still need to be further proved. The in vivo common eye irritation methods( winking,histopathological slices,Draize score and confocal microscopy test etc)were reviewed,eval-uated and analyzed in the paper.