中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2015年
2期
127-130
,共4页
韦贵将%杨凤莲%梁丽娜%梁丽梅%韦传东%罗斌%韦叶生%农乐根%唐毓金
韋貴將%楊鳳蓮%樑麗娜%樑麗梅%韋傳東%囉斌%韋葉生%農樂根%唐毓金
위귀장%양봉련%량려나%량려매%위전동%라빈%위협생%농악근%당육금
骨桥蛋白%多态性,单核苷酸%鼻咽肿瘤%单倍性
骨橋蛋白%多態性,單覈苷痠%鼻嚥腫瘤%單倍性
골교단백%다태성,단핵감산%비인종류%단배성
Osteopontin%Polymorphism,single nucleotide%Nasopharyngeal neoplasms%Haploidy
目的 研究骨桥蛋白基因单核苷酸多态性及其单倍型与广西壮族人群鼻咽癌易感性的关系.方法 采用病例对照研究方法,收集2010年3月1日至2013年3月20日入院的广西壮族鼻咽癌患者,同时直接抽样法选取2012年1月1日至8月1日常规体检的广西壮族健康人群作为对照.利用单碱基延伸PCR技术和DNA测序法,检测150例广西壮族鼻咽癌患者和150名壮族对照者的骨桥蛋白基因rs1126772和rs9138位点单核苷酸多态性,再用x2检验比较基因型和等位基因型分布频率在鼻咽癌组和对照组之间的差异,并分析骨桥蛋白基因的单倍型频率.结果 骨桥蛋白基因位点rs1126772在病例组和对照组间的基因型和等位基因型频率分布差异无统计学意义(GA/GG:OR=0.94,95% CI0.37 ~2.37,x2=0.182,P=0.891; AA/GG:OR=0.86,95% CI0.35 ~2.12,x2=0.834,P=0.773).rs9138位点在病例组和对照组间的基因型和等位基因型频率差异也无统计学意义(CA/CC:OR=1.42,95% CI0.88 ~2.29,x2=2.023,P=0.155; AA/CC:OR=1.77,95% CI0.78~4.01,x2=1.901,P=0.168).但是,单倍型分析结果显示,病例组GA单倍型频率显著高于对照组(P=0.003),GA单倍型携带者罹患鼻咽癌的风险显著增加(OR=4.84,95% CI 1.59~ 14.71).结论 在广西壮族人群中,骨桥蛋白基因位点rs 1126772和rs9138的GA单倍型增加个体鼻咽癌的易感性.
目的 研究骨橋蛋白基因單覈苷痠多態性及其單倍型與廣西壯族人群鼻嚥癌易感性的關繫.方法 採用病例對照研究方法,收集2010年3月1日至2013年3月20日入院的廣西壯族鼻嚥癌患者,同時直接抽樣法選取2012年1月1日至8月1日常規體檢的廣西壯族健康人群作為對照.利用單堿基延伸PCR技術和DNA測序法,檢測150例廣西壯族鼻嚥癌患者和150名壯族對照者的骨橋蛋白基因rs1126772和rs9138位點單覈苷痠多態性,再用x2檢驗比較基因型和等位基因型分佈頻率在鼻嚥癌組和對照組之間的差異,併分析骨橋蛋白基因的單倍型頻率.結果 骨橋蛋白基因位點rs1126772在病例組和對照組間的基因型和等位基因型頻率分佈差異無統計學意義(GA/GG:OR=0.94,95% CI0.37 ~2.37,x2=0.182,P=0.891; AA/GG:OR=0.86,95% CI0.35 ~2.12,x2=0.834,P=0.773).rs9138位點在病例組和對照組間的基因型和等位基因型頻率差異也無統計學意義(CA/CC:OR=1.42,95% CI0.88 ~2.29,x2=2.023,P=0.155; AA/CC:OR=1.77,95% CI0.78~4.01,x2=1.901,P=0.168).但是,單倍型分析結果顯示,病例組GA單倍型頻率顯著高于對照組(P=0.003),GA單倍型攜帶者罹患鼻嚥癌的風險顯著增加(OR=4.84,95% CI 1.59~ 14.71).結論 在廣西壯族人群中,骨橋蛋白基因位點rs 1126772和rs9138的GA單倍型增加箇體鼻嚥癌的易感性.
목적 연구골교단백기인단핵감산다태성급기단배형여엄서장족인군비인암역감성적관계.방법 채용병례대조연구방법,수집2010년3월1일지2013년3월20일입원적엄서장족비인암환자,동시직접추양법선취2012년1월1일지8월1일상규체검적엄서장족건강인군작위대조.이용단감기연신PCR기술화DNA측서법,검측150례엄서장족비인암환자화150명장족대조자적골교단백기인rs1126772화rs9138위점단핵감산다태성,재용x2검험비교기인형화등위기인형분포빈솔재비인암조화대조조지간적차이,병분석골교단백기인적단배형빈솔.결과 골교단백기인위점rs1126772재병례조화대조조간적기인형화등위기인형빈솔분포차이무통계학의의(GA/GG:OR=0.94,95% CI0.37 ~2.37,x2=0.182,P=0.891; AA/GG:OR=0.86,95% CI0.35 ~2.12,x2=0.834,P=0.773).rs9138위점재병례조화대조조간적기인형화등위기인형빈솔차이야무통계학의의(CA/CC:OR=1.42,95% CI0.88 ~2.29,x2=2.023,P=0.155; AA/CC:OR=1.77,95% CI0.78~4.01,x2=1.901,P=0.168).단시,단배형분석결과현시,병례조GA단배형빈솔현저고우대조조(P=0.003),GA단배형휴대자리환비인암적풍험현저증가(OR=4.84,95% CI 1.59~ 14.71).결론 재엄서장족인군중,골교단백기인위점rs 1126772화rs9138적GA단배형증가개체비인암적역감성.
Objective To evaluate the relationship between osteopontin gene genetic polymorphisms and susceptibility of nasopharyngeal carcinoma in Guangxi Zhuang people.Methods With a hospital based case-control study,osteopontin gene polymorphisms were compared between patients with nasopharyngeal carcinoma and healthy outpatients as a controls in Zhuang population in Guangxi.The single nucleotide polymorphisms at rs1126772 and rs9138 sites of the osteopontin gene were determined by polymerase chain reaction-single base extension technique (PCR-SBE) and DNA sequencing technology.The comparison between genotype and allele frequency distribution differences in case and control group was accomplished by a x2 test.The frequencies of haplotypes in osteopontin gene in different groups were analyzed.Results There were no differences between the patients and controls in the genotype or allele frequencies of osteopontin gene rs1126772 site(GA/GG:OR =0.94,95% CI 0.37-2.37,x2 =0.182,P =0.891 ; AA/GG:OR =0.86,95% CI0.35-2.12,x2 =0.834,P=0.773) or rs9138 site(CA/CC:OR =1.42,95%CI 0.88-2.29,x2 =2.023,P=0.155; AA/CC:OR=1.77,95%CI0.78-4.01,x2 =1.901,P=0.168).The frequency of GA haplotype in the patients was significantly higher than that in the controls (P =0.003),and the GA haplotype was associated with a significantly increased risk of nasopharyngeal carcinoma (OR =4.84,95% CI 1.59-14.71).Conclusion The haplotype GA of osteopontin gene rs1126772 and rs9138 sites increases the risk of nasopharyngeal carcinoma in Guangxi Zhuang people.