中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2015年
2期
121-125
,共5页
郭延娈%李建彬%李奉祥%丁昀%刘姗姗%段益利%尚东平%付政
郭延孌%李建彬%李奉祥%丁昀%劉姍姍%段益利%尚東平%付政
곽연련%리건빈%리봉상%정윤%류산산%단익리%상동평%부정
体层摄影术,正电子发射,氟脱氧葡萄糖%标准摄取值%体层摄影术,X线计算机,四维%内大体肿瘤体积%食管肿瘤/放射疗法
體層攝影術,正電子髮射,氟脫氧葡萄糖%標準攝取值%體層攝影術,X線計算機,四維%內大體腫瘤體積%食管腫瘤/放射療法
체층섭영술,정전자발사,불탈양포도당%표준섭취치%체층섭영술,X선계산궤,사유%내대체종류체적%식관종류/방사요법
Tomography,positron-emission,fluorodeoxyglucose%Standardized uptake value%Tomography,X-ray computed,four-dimensional%Internal gross target volume%Esophageal neoplasms/radiotherapy
目的 探讨基于PET-CT图像SUV阈值≥2.O及20％ SUVmax与基于4DCT的EE时相图像勾画胸段食管癌原发肿瘤GTV相关性因素.方法 22例胸段食管癌患者序贯完成3DCT、4DCT、FDG PET-CT胸部定位扫描.基于4DCT的EE时相图像勾画GTV50％.基于SUV≥2.0、20％SUVmax分别在PET图像上勾画IGTVPET并分别命名为IGTVPET2.0、IGTVPET20％.获得GTV50％最大横径、GTV50％大小、上下方向位移、三维运动矢量和SUVmax.结果 IGTVPET2.0、IGTVPE20％与GTV50％间体积比与GTV50％最大横径、GTV50％大小、上下方向位移、三维运动矢量均无相关性(P=0.055 ～0.932);IGTVPET2.0、IGTVPET20％与GTV50％间CI与GTV50％最大横径、GTV50％大小、上下方向位移、三维运动矢量均有相关性(P=0.005～0.033);IGTVPET20％与GTV50％间体积比、CI与SUVmax均有相关性(P =0.001、0.016).结论 基于PET-CT图像构建的IGTV并不能客观真实反映肿瘤空间位置变化及运动信息,而且单一数值的SUV阈值选取也是不可靠的.构建食管癌原发肿瘤靶区时应依据4DCT所构建IGTV纠正PET-CT所构建IGTV边界及其位置.
目的 探討基于PET-CT圖像SUV閾值≥2.O及20％ SUVmax與基于4DCT的EE時相圖像勾畫胸段食管癌原髮腫瘤GTV相關性因素.方法 22例胸段食管癌患者序貫完成3DCT、4DCT、FDG PET-CT胸部定位掃描.基于4DCT的EE時相圖像勾畫GTV50％.基于SUV≥2.0、20％SUVmax分彆在PET圖像上勾畫IGTVPET併分彆命名為IGTVPET2.0、IGTVPET20％.穫得GTV50％最大橫徑、GTV50％大小、上下方嚮位移、三維運動矢量和SUVmax.結果 IGTVPET2.0、IGTVPE20％與GTV50％間體積比與GTV50％最大橫徑、GTV50％大小、上下方嚮位移、三維運動矢量均無相關性(P=0.055 ～0.932);IGTVPET2.0、IGTVPET20％與GTV50％間CI與GTV50％最大橫徑、GTV50％大小、上下方嚮位移、三維運動矢量均有相關性(P=0.005～0.033);IGTVPET20％與GTV50％間體積比、CI與SUVmax均有相關性(P =0.001、0.016).結論 基于PET-CT圖像構建的IGTV併不能客觀真實反映腫瘤空間位置變化及運動信息,而且單一數值的SUV閾值選取也是不可靠的.構建食管癌原髮腫瘤靶區時應依據4DCT所構建IGTV糾正PET-CT所構建IGTV邊界及其位置.
목적 탐토기우PET-CT도상SUV역치≥2.O급20％ SUVmax여기우4DCT적EE시상도상구화흉단식관암원발종류GTV상관성인소.방법 22례흉단식관암환자서관완성3DCT、4DCT、FDG PET-CT흉부정위소묘.기우4DCT적EE시상도상구화GTV50％.기우SUV≥2.0、20％SUVmax분별재PET도상상구화IGTVPET병분별명명위IGTVPET2.0、IGTVPET20％.획득GTV50％최대횡경、GTV50％대소、상하방향위이、삼유운동시량화SUVmax.결과 IGTVPET2.0、IGTVPE20％여GTV50％간체적비여GTV50％최대횡경、GTV50％대소、상하방향위이、삼유운동시량균무상관성(P=0.055 ～0.932);IGTVPET2.0、IGTVPET20％여GTV50％간CI여GTV50％최대횡경、GTV50％대소、상하방향위이、삼유운동시량균유상관성(P=0.005～0.033);IGTVPET20％여GTV50％간체적비、CI여SUVmax균유상관성(P =0.001、0.016).결론 기우PET-CT도상구건적IGTV병불능객관진실반영종류공간위치변화급운동신식,이차단일수치적SUV역치선취야시불가고적.구건식관암원발종류파구시응의거4DCT소구건IGTV규정PET-CT소구건IGTV변계급기위치.
Objective To investigate the correlation factors in delineating the gross tumor volume (GTV) of primary tumor in thoracic esophageal cancer based on the positron emission tomography-computed tomography (PET-CT) (thresholds of standardized uptake value or SUV ≥2.0 and ≥20％ of maximum SUV or SUVmax) and the end-expiration (EE) phase of four-dimensional computed tomography (4DCT).Methods Twenty-two patients with thoracic esophageal cancer sequentially underwent 3DCT,4DCT,and F-fluorodeoxyglucose PET-CT for thoracic localization.GTV50％ was delineated by the EE phase of 4DCT.The internal GTVs based on PET-CT images (IGTVPET) were delineated by two thresholds:SUV ≥2.0 and ≥20％ of SUVmax,and designated as IGTVPET2.0 and IGTVPT20％,respectively.The maximum transverse diameter of GTV50％,volume of GTV50％,the displacement in cranial-caudal (CC) direction,3D motion vector,and SUVmax were obtained.Results The maximum transverse diameter of GTV50％,volume of GTV50％,the displacement in CC direction,and 3D motion vector showed no significant correlations with the volume ratio (VR) of IGTVPTV20％ or IGTVPET2.0 to GTV50％ (P =0.055-0.932),but showed significant correlations with the conformity index (CI) between IGTVPET20％ or IGTVPET2.0 and GTV50％ (P =0.005-0.033).Significant correlations were observed between the VR and CI of IGTVPET20％ to GTV50％ and SUVmax(P =0.001 and 0.016,respectively).Conclusions IGTV based on PET-CT images cannot objectively and accurately reflect the changes in spatial position and motion of the tumor,and the selection of a single SUV threshold is unreliable.To determine the primary tumor target in esophageal cancer,the IGTV based on 4DCT should be used to correct the boundary and position of IGTV constructed based on PET-CT.
