中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
4期
595-597
,共3页
干扰素α-2b%青光眼滤过术%术后瘢痕%丝裂霉素C
榦擾素α-2b%青光眼濾過術%術後瘢痕%絲裂黴素C
간우소α-2b%청광안려과술%술후반흔%사렬매소C
Interferon α-2b%Glaucoma filtering surgery%Postoperative scar%Mitomycin C
目的：探讨干扰素α-2b在抗青光眼滤过术后瘢痕形成的应用。方法：原发性青光眼患者62例（68眼），随机分为观察组31例（36眼）、对照组31例（32眼），观察组患者术中给予干扰素α-2b浸润的棉片湿敷，而对照组给予丝裂霉素C浸润的棉片进行湿敷，术后随访4个月，比较两组患者术后滤过泡类型、并发症、眼压变化情况。结果：观察组患者以II型滤过泡为主（58.33%）、对照组患者以I型滤过泡为主（53.13%），两组滤过泡类型比较差异具有统计学意义（P<0.05）；两组患者术后各时间点眼压与术前比较，均有显著降低（P<0.05）；两组间各时间点眼压差异均无统计学意义（P>0.05）。观察组术后视力不变或提高的比例显著高于对照组（ P<0.05）；且观察组患者发生术后并发症发生率显著低于对照组（ P<0.05）。结论：干扰素α-2b是一种较为理想的抗青光眼滤过术后瘢痕形成药物。
目的：探討榦擾素α-2b在抗青光眼濾過術後瘢痕形成的應用。方法：原髮性青光眼患者62例（68眼），隨機分為觀察組31例（36眼）、對照組31例（32眼），觀察組患者術中給予榦擾素α-2b浸潤的棉片濕敷，而對照組給予絲裂黴素C浸潤的棉片進行濕敷，術後隨訪4箇月，比較兩組患者術後濾過泡類型、併髮癥、眼壓變化情況。結果：觀察組患者以II型濾過泡為主（58.33%）、對照組患者以I型濾過泡為主（53.13%），兩組濾過泡類型比較差異具有統計學意義（P<0.05）；兩組患者術後各時間點眼壓與術前比較，均有顯著降低（P<0.05）；兩組間各時間點眼壓差異均無統計學意義（P>0.05）。觀察組術後視力不變或提高的比例顯著高于對照組（ P<0.05）；且觀察組患者髮生術後併髮癥髮生率顯著低于對照組（ P<0.05）。結論：榦擾素α-2b是一種較為理想的抗青光眼濾過術後瘢痕形成藥物。
목적：탐토간우소α-2b재항청광안려과술후반흔형성적응용。방법：원발성청광안환자62례（68안），수궤분위관찰조31례（36안）、대조조31례（32안），관찰조환자술중급여간우소α-2b침윤적면편습부，이대조조급여사렬매소C침윤적면편진행습부，술후수방4개월，비교량조환자술후려과포류형、병발증、안압변화정황。결과：관찰조환자이II형려과포위주（58.33%）、대조조환자이I형려과포위주（53.13%），량조려과포류형비교차이구유통계학의의（P<0.05）；량조환자술후각시간점안압여술전비교，균유현저강저（P<0.05）；량조간각시간점안압차이균무통계학의의（P>0.05）。관찰조술후시력불변혹제고적비례현저고우대조조（ P<0.05）；차관찰조환자발생술후병발증발생솔현저저우대조조（ P<0.05）。결론：간우소α-2b시일충교위이상적항청광안려과술후반흔형성약물。
Objective:To investigate the preventive efficacy of interferon α -2b on scar formation after glaucoma filtering opera-tion. Methods:Totally 62 patients with primary glaucoma(68 eyes)were randomly divided into the observation group(31 cases with 36 eyes)and the control group(31 cases with 32 eyes). The patients in the observation group were given wet compress with a piece of cotton infiltrated by interferonα-2b,while the control group was given wet compress with a piece of cotton infiltrated by mitomycin C. After 4-month postoperative follow-up,the type of filtering bleb,complications and the changes of intraocular pressure were compared between the two groups. Results:The observation group was mainly with type II bleb(58. 33%),while the control group was mainly with type I bleb(53. 13%),and there was significant difference in the filtering bleb type between the two groups(P<0. 05). After the operation,the intraocular pressure at each time point in the two groups was decreased significantly when compared with that before the operation(P<0. 05),while the difference between the two groups was not statistically significant(P>0. 05). The percentage of visual invariableness or improvement in the observation group was significantly higher than that in the control group(P<0. 05),and the occurrence of complications after the operation in the observation group was significantly lower than that in the control group( P<0. 05). Conclusion:Interferon α-2b is an ideal drug for anti-scarring formation after glaucoma filtration surgery.
