CAJ | 학술논문

目的：探讨加巴喷丁（ GBP）联合阿米替林、曲马多治疗带状疱疹后神经痛（ PHü）伴焦虑患者的临床效果。方法：选择伴不同程度焦虑症状的PHü患者106例，随机分为观察组和对照组各53例，观察组给予GBP胶囊联合阿米替林片、曲马多缓释片；对照组单用GBP胶囊治疗，分别于用药前、用药后第1周、第4周对患者焦虑、抑郁状态，生活质量以及镇痛程度进行VAS评分，评价临床治疗效果。结果：用药第1周和第4周开始，两组焦虑状态、抑郁状态评分，生活质量以及VAS评分均较治疗前明显降低（ P<0.05），且观察组评分较对照组下降更为显著（ P<0.05）。观察组不良反应发生率明显低于对照组（ P<0.05）。结论：GBP联合曲马多、阿米替林治疗PHü伴焦虑的患者，能有效降低患者的VAS评分，提高患者的生活质量。
목적：탐토가파분정（ GBP）연합아미체림、곡마다치료대상포진후신경통（ PHü）반초필환자적림상효과。방법：선택반불동정도초필증상적PHü환자106례，수궤분위관찰조화대조조각53례，관찰조급여GBP효낭연합아미체림편、곡마다완석편；대조조단용GBP효낭치료，분별우용약전、용약후제1주、제4주대환자초필、억욱상태，생활질량이급진통정도진행VAS평분，평개림상치료효과。결과：용약제1주화제4주개시，량조초필상태、억욱상태평분，생활질량이급VAS평분균교치료전명현강저（ P<0.05），차관찰조평분교대조조하강경위현저（ P<0.05）。관찰조불량반응발생솔명현저우대조조（ P<0.05）。결론：GBP연합곡마다、아미체림치료PHü반초필적환자，능유효강저환자적VAS평분，제고환자적생활질량。
Objective:To investigate the clinical efficacy of gabapentin capsules( GBP)combined with amitriptyline and tramadol in the treatment of patients with postherpetic neuralgia( PHü)and anxiety. Methods:Totally 106 PHü patients with anxiety symptoms at different degree were selected and divided into group A(n=53)and group B(n=53). Group A was given GBP,amitriptyline and tramadol,while group was given GBP only. The anxiety,depression,quality of life and pain-relieving intensity( by VAS)of the pa-tients were determined before the medication( T1 )and in the first week( T2 )and the fourth week( T3 )after the medication. Follow-up was carried out regularly according to the requirements to evaluate the clinical efficacy. Results:The anxiety,depression and VAS scores in the two groups on T2 were statistically significant lower than the corresponding results on T1(P<0.05). On T3,however, there were statistically significant differences between the two groups(P<0. 05). The total adverse reaction rate of group A was signif-icantly lower than that of group B(P<0. 05). The total effective rate of group A was significantly higher than that of group B(P<0. 05). Conclusion:GBP combined with tramadol and amitriptyline in the treatment of PHü patients with anxiety can effectively con-trol the pain of the patients,significantly reduce the scores of VAS and improve the quality of life of the patients.