中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
4期
484-486
,共3页
段彦彦%裴保方%陈海燕%陶兴茹%刘晓玲%曹松山
段彥彥%裴保方%陳海燕%陶興茹%劉曉玲%曹鬆山
단언언%배보방%진해연%도흥여%류효령%조송산
儿童%超说明书%抗肿瘤药%用药分析
兒童%超說明書%抗腫瘤藥%用藥分析
인동%초설명서%항종류약%용약분석
Children%Off-label drug use%Antineoplastic drug%Analysis of drug use
目的：了解河南省郑州市儿童医院（以下简称“我院”）儿童超说明书使用抗肿瘤药的情况，促进临床合理用药。方法：抽取我院2013年7—12月出院归档病历中应用了抗肿瘤药的医嘱，根据药品说明书分析超说明书用药情况。结果：共抽取595份病历含6497条抗肿瘤药用药医嘱。其中超说明书用药病历数429份，占72．10％；用药医嘱1606条，占24．72％。超说明书用药发生率较高者依次为烷化剂（79．56％）、抗肿瘤抗菌药物（62．26％）及植物来源的抗肿瘤药（31．38％）；超说明书用药类型前3位者依次为超单次剂量（47．38％）、超适应证（27．11％）及超给药途径（17．56％）；超说明书医嘱数排名前3位的抗肿瘤药依次为亚叶酸钙针（551份）、依托泊苷针（482份）、环磷酰胺针（373份）。结论：我院抗肿瘤药超说明书使用普遍存在，部分超说明书使用有一定的循证学依据。需加强用药监管，规范用药，以确保儿童安全、合理用药。
目的：瞭解河南省鄭州市兒童醫院（以下簡稱“我院”）兒童超說明書使用抗腫瘤藥的情況，促進臨床閤理用藥。方法：抽取我院2013年7—12月齣院歸檔病歷中應用瞭抗腫瘤藥的醫囑，根據藥品說明書分析超說明書用藥情況。結果：共抽取595份病歷含6497條抗腫瘤藥用藥醫囑。其中超說明書用藥病歷數429份，佔72．10％；用藥醫囑1606條，佔24．72％。超說明書用藥髮生率較高者依次為烷化劑（79．56％）、抗腫瘤抗菌藥物（62．26％）及植物來源的抗腫瘤藥（31．38％）；超說明書用藥類型前3位者依次為超單次劑量（47．38％）、超適應證（27．11％）及超給藥途徑（17．56％）；超說明書醫囑數排名前3位的抗腫瘤藥依次為亞葉痠鈣針（551份）、依託泊苷針（482份）、環燐酰胺針（373份）。結論：我院抗腫瘤藥超說明書使用普遍存在，部分超說明書使用有一定的循證學依據。需加彊用藥鑑管，規範用藥，以確保兒童安全、閤理用藥。
목적：료해하남성정주시인동의원（이하간칭“아원”）인동초설명서사용항종류약적정황，촉진림상합리용약。방법：추취아원2013년7—12월출원귀당병력중응용료항종류약적의촉，근거약품설명서분석초설명서용약정황。결과：공추취595빈병력함6497조항종류약용약의촉。기중초설명서용약병력수429빈，점72．10％；용약의촉1606조，점24．72％。초설명서용약발생솔교고자의차위완화제（79．56％）、항종류항균약물（62．26％）급식물래원적항종류약（31．38％）；초설명서용약류형전3위자의차위초단차제량（47．38％）、초괄응증（27．11％）급초급약도경（17．56％）；초설명서의촉수배명전3위적항종류약의차위아협산개침（551빈）、의탁박감침（482빈）、배린선알침（373빈）。결론：아원항종류약초설명서사용보편존재，부분초설명서사용유일정적순증학의거。수가강용약감관，규범용약，이학보인동안전、합리용약。
OBJECTIVE:To investigate the off-label use of antineoplastic drugs in Zhengzhou Children's Hospital ( hereinafter referred to as“our hospital”) in order to promote clinical rational use of drug.METHODS:The medical records of the patients who had been treated with antineoplastic drugs discharged from our hospital during July-December period of 2013 were analyzed with regard to off-label drug use.RESULTS: A total of 595 medical records containing 6 497 antineoplastic medication orders were reviewed.The off-label drug use was noted in 429 medical records, accounting for 72.10%and there were a total of 1 606 off-label medication orders, accounting for 24.72%. The drugs ranked in descending order in the incidence of off-label use were alkylating agents ( 79.56%) , antitumor antibiotics (62.26%) and plant-derived anticancer drugs (31.38%) .The top three types of off-label use were off-label single dose (47.38%), off-label indications (27.11%) and off-label route of administration (17.56%).The top three antineoplastic ranked by number of off-label medical orders were Calcium Folinate-SF injections ( 551 ) , etoposide injections ( 482 ) and cyclophosphamide injections ( 373 ) . CONCLUSIONS: The off-label use of antineoplastic drugs is common in our hospital, and some off-label use is evidence-based, is evidence-based learning, however, it is important to tighten monitoring on the use of antineoplastic drugs and standardize their use so as to safe and rational ensure medication safety among children.
