CAJ | 학술논문

目的：探讨0.9%氯化钠溶液在42℃保温箱中的保存期限及成本分析。方法选择80瓶0.9%氯化钠溶液作为研究对象,使用统计软件SAS 9.2随机分成对照组和保温组,每组各40瓶,对照组置于层流洁净手术室室温下,保温组置于42℃保温箱中。各组分别于5个时间点(实验开始后3 d、1周、2周、3周、4周)各取8瓶检测其细菌培养的菌落数和pH值的变化。在前期实验的基础上随后选取12个手术间,随机分为A组和B组,各6个手术间。 A组由保温箱A供应温0.9%氯化钠溶液,保存期限3 d；B组由保温箱B供应温0.9%氯化钠溶液,保存期限4周。结果两组0.9%氯化钠溶液细菌培养均为阴性。对照组5个时间点pH值分别为(6.35±0.29),(6.32±0.04),(6.23±0.20),(6.29±0.35),(6.36±0.32)；保温组5个时间点pH值分别为(6.37±0.42),(6.31±0.11),(6.39±0.21),(6.42±0.45),(6.60±0.32),两组同一时间点pH值差异无统计学意义(t值分别为0.1108,0.2417,1.5610,0.6450,2.1110；P >0.05)。 A 组0.9%氯化钠溶液消耗量为(2761±118)瓶,成本为(11042±470)元,B组消耗量为(1466±205)瓶,成本为(5862±820)元,两组比较差异均有统计学意义(t=13.41；P<0.01)。结论0.9%氯化钠溶液在42℃保温箱中的保存期限可延长至4周,检测指标符合药典要求,可降低其用量并节约成本。
목적：탐토0.9%록화납용액재42℃보온상중적보존기한급성본분석。방법선택80병0.9%록화납용액작위연구대상,사용통계연건SAS 9.2수궤분성대조조화보온조,매조각40병,대조조치우층류길정수술실실온하,보온조치우42℃보온상중。각조분별우5개시간점(실험개시후3 d、1주、2주、3주、4주)각취8병검측기세균배양적균락수화pH치적변화。재전기실험적기출상수후선취12개수술간,수궤분위A조화B조,각6개수술간。 A조유보온상A공응온0.9%록화납용액,보존기한3 d；B조유보온상B공응온0.9%록화납용액,보존기한4주。결과량조0.9%록화납용액세균배양균위음성。대조조5개시간점pH치분별위(6.35±0.29),(6.32±0.04),(6.23±0.20),(6.29±0.35),(6.36±0.32)；보온조5개시간점pH치분별위(6.37±0.42),(6.31±0.11),(6.39±0.21),(6.42±0.45),(6.60±0.32),량조동일시간점pH치차이무통계학의의(t치분별위0.1108,0.2417,1.5610,0.6450,2.1110；P >0.05)。 A 조0.9%록화납용액소모량위(2761±118)병,성본위(11042±470)원,B조소모량위(1466±205)병,성본위(5862±820)원,량조비교차이균유통계학의의(t=13.41；P<0.01)。결론0.9%록화납용액재42℃보온상중적보존기한가연장지4주,검측지표부합약전요구,가강저기용량병절약성본。
Objective To explore the storage life and cost analysis of 0. 9% sodium chloride solution in 42℃ conveuse. Methods A total of 80 bottles of 0. 9% sodium chloride solution had been selected as research sampling, and the SAS 9. 2 were used to randomly divide them into control group (put sampling in clean laminar flow operation room at room temperature) and experimental group ( put in 42℃ conveuse) on average. Eight bottles of each group were took out for the number of colony examination after germiculture and the change of pH value ( at the beginning of 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks experiment) . Basis on the previous experiment, we selected 12 operating room and randomly divided into A group and B group on average. A conveuse provided warm 0. 9% sodium chloride solution, which had three days storage life in A group, but B conveuse offered warm 0. 9% sodium chloride solution of 4 weeks storage life. Results The results of germiculture were negative in both group. The 5 time point of pH values were (6. 35 ± 0. 29), (6. 32 ± 0. 04), (6. 23 ± 0. 20), (6. 29 ± 0. 35), (6. 36 ± 0. 32) at the control group, while these of experimental group were (6.37 ±0.42), (6.31 ±0.11), (6.39 ±0.21), (6.42 ±0.45), (6.60 ±0.32)and at the same time point the pH value of two groups had no statistical significance (t=0. 110 8, 0. 241 7, 1. 561 0, 0. 645 0, 2. 111 0;P>0. 05). Compared with A group-consumed (2 761 ± 118) bottles, cost (11 042 ± 470) Yuan, B group consumed (1 466 ± 205) bottles and cost (5 862 ± 820) Yuan with statistical significance between two groups (t=13.41;P<0.01).Conclusions Thepreservationof0.9% sodiumchloridesolutionin42℃ conveusecan be maintained 4 weeks and reduced cost by the decreasing the number of usage, and the testing norm is accord with the acquirement of pharmacopeia.