四川精神卫生
四川精神衛生
사천정신위생
SICHUAN MENTAL HEALTH
2015年
2期
134-137
,共4页
精神分裂症%帕利哌酮缓释片%齐拉西酮%认知功能%生活质量
精神分裂癥%帕利哌酮緩釋片%齊拉西酮%認知功能%生活質量
정신분렬증%파리고동완석편%제랍서동%인지공능%생활질량
Schizophrenia%Paliperidone%Ziprasidone%Cognitive function%Quality of life
目的：探讨帕利哌酮与齐拉西酮对精神分裂症患者认知功能和生活质量的影响。方法采用随机数字表法将符合《国际疾病分类（第10版）》（ICD -10）精神分裂症诊断标准的96例精神分裂症患者分为帕利哌酮缓释片组（观察组）和齐拉西酮胶囊组（对照组）各48例，分别于治疗前和治疗8周后采用威斯康星卡片分类测验（WCST）和持续操作测验（CPT）测评认知功能，采用世界卫生组织生存质量简表（WHOQOL - BREF）测评生活质量。结果治疗8周后观察组 WCST 中的正确应答数、持续性错误数较对照组改善，差异有统计学意义（t =2.294、2.049，P <0.05）。观察组 CPT2及 CPT3较对照组改善，差异有统计学意义（t =2.242，P <0.05；t =2.671，P <0.01）。观察组在WHOQOL - BREF 的生理领域、心理领域及社会关系领域较对照组改善，差异有统计学意义（t =2.465、2.166、2.444，P<0.05）。结论帕利哌酮缓释片对改善精神分裂症患者的认知功能和生活质量优于齐拉西酮。
目的：探討帕利哌酮與齊拉西酮對精神分裂癥患者認知功能和生活質量的影響。方法採用隨機數字錶法將符閤《國際疾病分類（第10版）》（ICD -10）精神分裂癥診斷標準的96例精神分裂癥患者分為帕利哌酮緩釋片組（觀察組）和齊拉西酮膠囊組（對照組）各48例，分彆于治療前和治療8週後採用威斯康星卡片分類測驗（WCST）和持續操作測驗（CPT）測評認知功能，採用世界衛生組織生存質量簡錶（WHOQOL - BREF）測評生活質量。結果治療8週後觀察組 WCST 中的正確應答數、持續性錯誤數較對照組改善，差異有統計學意義（t =2.294、2.049，P <0.05）。觀察組 CPT2及 CPT3較對照組改善，差異有統計學意義（t =2.242，P <0.05；t =2.671，P <0.01）。觀察組在WHOQOL - BREF 的生理領域、心理領域及社會關繫領域較對照組改善，差異有統計學意義（t =2.465、2.166、2.444，P<0.05）。結論帕利哌酮緩釋片對改善精神分裂癥患者的認知功能和生活質量優于齊拉西酮。
목적：탐토파리고동여제랍서동대정신분렬증환자인지공능화생활질량적영향。방법채용수궤수자표법장부합《국제질병분류（제10판）》（ICD -10）정신분렬증진단표준적96례정신분렬증환자분위파리고동완석편조（관찰조）화제랍서동효낭조（대조조）각48례，분별우치료전화치료8주후채용위사강성잡편분류측험（WCST）화지속조작측험（CPT）측평인지공능，채용세계위생조직생존질량간표（WHOQOL - BREF）측평생활질량。결과치료8주후관찰조 WCST 중적정학응답수、지속성착오수교대조조개선，차이유통계학의의（t =2.294、2.049，P <0.05）。관찰조 CPT2급 CPT3교대조조개선，차이유통계학의의（t =2.242，P <0.05；t =2.671，P <0.01）。관찰조재WHOQOL - BREF 적생리영역、심리영역급사회관계영역교대조조개선，차이유통계학의의（t =2.465、2.166、2.444，P<0.05）。결론파리고동완석편대개선정신분렬증환자적인지공능화생활질량우우제랍서동。
Objective To explore the influence of paliperidone and ziprasidone on the cognitive function and quality of life in pa-tients with schizophrenia. Methods 96 cases of schizophrenia patients conform to the International classification of diseases tenth edi-tion(ICD - 10)were randomly divided into paliperidone group(observation group,48 cases)and ziprasidone capsule group(control group,48 cases)by using the random number table method. Two groups of patients were assessed by Wisconsin Card Sorting Test (WCST),Continuous Performance Test(CPT)to evaluate cognitive function and using WHO Quality of Life - BREF(WHOQOL -BREF)to evaluate quality of life before and after 8 weeks of treatment. Results The scores of the number of correct response and per-sistent error number of WCST in observation group improved was statistically significant than control group after 8 weeks treatment(t =2. 294,t = 2. 049,P < 0. 05). The scores of the CPT2 and CPT3 in observation group improved was statistically significant than control group(t = 2. 242,P < 0. 05;t = 2. 671,P < 0. 01). The scores of the field of physiological,psychological and social relationship of WHOQOL - BREF in observation group improved was statistically significant than control group(t = 2. 465,2. 166,2. 444,P < 0. 05). Conclusion Paliperidone extended - release tablet can be effectively to improve the cognitive function and quality of life in patients with schizophrenia was better than ziprasidone.
