四川精神卫生
四川精神衛生
사천정신위생
SICHUAN MENTAL HEALTH
2015年
2期
131-133
,共3页
阿立哌唑%氯氮平%精神分裂症%认知功能
阿立哌唑%氯氮平%精神分裂癥%認知功能
아립고서%록담평%정신분렬증%인지공능
Aripiprazole%Clozapine%Schizophrenia%Cognitive function
目的：探讨氯氮平联合阿立哌唑对长期住院精神分裂症患者的疗效及对认知功能的影响。方法将67例符合《国际疾病分类（第10版）》（ICD -10）诊断标准的长期住院精神分裂症患者随机分为治疗组和对照组，两组实际完成研究各31例。治疗组给予氯氮平联合阿立哌唑治疗，对照组仅给予常规剂量氯氮平治疗，疗程12周；采用阳性与阴性症状量表（PANSS）评定疗效，采用威斯康星卡片（WCST）评定认知功能。结果治疗12周后，治疗组 PANSS 总评分、阴性症状评分较治疗前低，差异均有统计学意义（P <0.01）；WCST 评定总正确数、正确率、持续反应数、持续错误数、分类数均优于治疗前，差异有统计学意义（P <0.05）。对照组 PANSS 总评分、阳性症状评分、阴性症状评分与治疗前比较差异均无统计学意义（P ﹥0.05）；WCST 评定总正确数、正确率、持续反应数、持续错误数、分类数与治疗前比较差异均无统计学意义（P ﹥0.05）。结论氯氮平联合阿立哌唑治疗对改善长期住院精神分裂症患者的阴性症状及认知功能的效果可能优于单一使用氯氮平治疗。
目的：探討氯氮平聯閤阿立哌唑對長期住院精神分裂癥患者的療效及對認知功能的影響。方法將67例符閤《國際疾病分類（第10版）》（ICD -10）診斷標準的長期住院精神分裂癥患者隨機分為治療組和對照組，兩組實際完成研究各31例。治療組給予氯氮平聯閤阿立哌唑治療，對照組僅給予常規劑量氯氮平治療，療程12週；採用暘性與陰性癥狀量錶（PANSS）評定療效，採用威斯康星卡片（WCST）評定認知功能。結果治療12週後，治療組 PANSS 總評分、陰性癥狀評分較治療前低，差異均有統計學意義（P <0.01）；WCST 評定總正確數、正確率、持續反應數、持續錯誤數、分類數均優于治療前，差異有統計學意義（P <0.05）。對照組 PANSS 總評分、暘性癥狀評分、陰性癥狀評分與治療前比較差異均無統計學意義（P ﹥0.05）；WCST 評定總正確數、正確率、持續反應數、持續錯誤數、分類數與治療前比較差異均無統計學意義（P ﹥0.05）。結論氯氮平聯閤阿立哌唑治療對改善長期住院精神分裂癥患者的陰性癥狀及認知功能的效果可能優于單一使用氯氮平治療。
목적：탐토록담평연합아립고서대장기주원정신분렬증환자적료효급대인지공능적영향。방법장67례부합《국제질병분류（제10판）》（ICD -10）진단표준적장기주원정신분렬증환자수궤분위치료조화대조조，량조실제완성연구각31례。치료조급여록담평연합아립고서치료，대조조부급여상규제량록담평치료，료정12주；채용양성여음성증상량표（PANSS）평정료효，채용위사강성잡편（WCST）평정인지공능。결과치료12주후，치료조 PANSS 총평분、음성증상평분교치료전저，차이균유통계학의의（P <0.01）；WCST 평정총정학수、정학솔、지속반응수、지속착오수、분류수균우우치료전，차이유통계학의의（P <0.05）。대조조 PANSS 총평분、양성증상평분、음성증상평분여치료전비교차이균무통계학의의（P ﹥0.05）；WCST 평정총정학수、정학솔、지속반응수、지속착오수、분류수여치료전비교차이균무통계학의의（P ﹥0.05）。결론록담평연합아립고서치료대개선장기주원정신분렬증환자적음성증상급인지공능적효과가능우우단일사용록담평치료。
Objective To explore the effects of clozapine combined with aripiprazole on efficacy and cognitive function for long -term schizophrenic inpatients. Methods 67 long - term schizophrenic inpatients were randomly divided into study group and control group. 31patients in each group completed the study. The study group were treated with clozapine combined with aripiprazole and the control group were given clozapine in regular dose. The course of treatment was 12 weeks. Clinical efficacy was assessed by Positive and Negative Symptom Scale(PANSS),while cognitive function were evaluated by Wisconsion Card Sorting Test(WCST). Results At the end of the treatment,total scores of PANSS and negative symptoms score decreased significantly(P < 0. 001)and Response Correct (RC),RC% ,Response Perseverative(RP),Response Perseverative Errors(RPE)and Categories Completed(CC)of WCST were sig-nificantly improved when compared with those at baseline in the study group(P < 0. 05). There was no significant decrease occurred in total scores of PANSS,negative symptoms score and positive symptoms score(P ﹥ 0. 05)and no significantly improvement occurred in RC,RC% ,RP,RPE and CC of WCST when compared with those at baseline in the control group(P ﹥ 0. 05). Conclusion These findings suggest that clozapine combined with aripiprazole effectively improve the negative symptoms and cognitive functions in long -term schizophrenic inpatients.
