CAJ | 학술논문

目的：探讨联合阿立哌唑与单用奥氮平对精神分裂症患者体质量、糖脂代谢的影响。方法选择符合《国际疾病分类（第10版）》（ICD -10）诊断标准的精神分裂症患者100例，采用随机数字表法分为研究组和对照组各50例，研究组予奥氮平合并小剂量阿立哌唑治疗，对照组单一使用奥氮平治疗。于入组时及治疗后4周、12周、24周末评定临床疗效和测量血糖、血脂、载脂蛋白 A 和 B、胰岛素和 c 肽水平。结果治疗4周后，对照组和研究组治疗有效率分别为30.0%和40.0%，12周后分别为46.0%和56.0%，24周后分别为80.0%和90.0%，研究组有效率均高于对照组，差异有统计学意义（P <0.05）。对照组治疗24周后体质量、胸围、体质量指数（BMI）、空腹血糖、胰岛素（INS）和胰岛素抵抗（IR）水平与治疗前相比，差异有统计学意义（P <0.05）；而研究组治疗24周后各指标值与治疗前相比，差异无统计学意义（P ﹥0.05）。对照组治疗24周后血脂代谢各指标值与治疗前相比，差异有统计学意义（P <0.05）；而研究组治疗24周后与治疗前相比，差异无统计学意义（P ﹥0.05）。结论奥氮平联合小剂量阿立哌唑对精神分裂症的疗效以及对体质量和糖脂代谢的影响可能优于单用奥氮平。
목적：탐토연합아립고서여단용오담평대정신분렬증환자체질량、당지대사적영향。방법선택부합《국제질병분류（제10판）》（ICD -10）진단표준적정신분렬증환자100례，채용수궤수자표법분위연구조화대조조각50례，연구조여오담평합병소제량아립고서치료，대조조단일사용오담평치료。우입조시급치료후4주、12주、24주말평정림상료효화측량혈당、혈지、재지단백 A 화 B、이도소화 c 태수평。결과치료4주후，대조조화연구조치료유효솔분별위30.0%화40.0%，12주후분별위46.0%화56.0%，24주후분별위80.0%화90.0%，연구조유효솔균고우대조조，차이유통계학의의（P <0.05）。대조조치료24주후체질량、흉위、체질량지수（BMI）、공복혈당、이도소（INS）화이도소저항（IR）수평여치료전상비，차이유통계학의의（P <0.05）；이연구조치료24주후각지표치여치료전상비，차이무통계학의의（P ﹥0.05）。대조조치료24주후혈지대사각지표치여치료전상비，차이유통계학의의（P <0.05）；이연구조치료24주후여치료전상비，차이무통계학의의（P ﹥0.05）。결론오담평연합소제량아립고서대정신분렬증적료효이급대체질량화당지대사적영향가능우우단용오담평。
Objective To investigate the effect of combination of aripiprazole with olanzapine and olanzapine on weight and glu-colipid metabolism of patients with schizophrenia. Methods 100 cases of schizophrenia patients were randomly divided into control group and research group with number table,50 cases in each group. Patients in research group were administrated with combination of aripiprazole with olanzapine,while patients in control group received olanzapine. The curative effect,blood glucose,blood lipid,apoli-poprotein A and B,insulin and c peptide were determined at the time point of before treatment,after treatment 4,12,24 weeks. Re-sults After treatment for four weeks,the effective rate of research group and control group were 30. 0% and 40. 0% ,12 weeks was 46. 0% and 56. 0% ,24 weeks was 80. 0% and 90. 0% ,with significant difference(P < 0. 05). For control group,the weight,chest circumference,body mass,FBS,INS and IR significantly increased after 24 weeks(P < 0. 05). For research group,after 24 weeks, all these indices did not significantly change(P ﹥ 0. 05). The blood lipid indices significantly changed(P < 0. 05),while no for re-search group(P ﹥ 0. 05). Conclusion Treatment of schizophrenia using the combination of aripiprazole with olanzapine could en-hance the curative effect,decrease the side effect on body mass,slow down the glucolipid metabolism disorder,and increase the com-pliance and life quality.