中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
12期
97-99
,共3页
阿托伐他汀钙%脑梗死%血浆脂蛋白磷脂酶A2
阿託伐他汀鈣%腦梗死%血漿脂蛋白燐脂酶A2
아탁벌타정개%뇌경사%혈장지단백린지매A2
Atorvastatin calcium%Cerebral infarction%Plasma lipoprotein-associated phospholipase A2
目的：分析不同剂量阿托伐他汀钙治疗动脉粥样硬化性脑梗死的临床效果及对血浆脂蛋白磷脂酶A2（Lp-PLA2）的影响。方法选取2013年12月~2014年10月本院确诊收治的100例动脉粥样硬化性脑梗死患者作为研究对象，随机分为对照组和治疗组，各50例。对照组患者给予常规治疗+阿托伐他汀钙10 mg/d治疗，治疗组患者给予常规治疗+阿托伐他汀钙40 mg/d治疗。观察两组患者的临床治疗效果、血脂、炎症因子Lp-PLA2变化情况，并作对比分析。结果治疗组治疗后的血脂、Lp-PLA2水平改善优于对照组（P<0.05）；治疗组的总有效率为84%，明显高于对照组的66%，差异有统计学意义（P<0.05）；两组无严重不良反应。结论阿托伐他汀钙治疗动脉粥样硬化性脑梗死，不仅能常规调节血脂水平，还能降低炎症因子Lp-PLA2的水平，有较好的临床效果，强化治疗40 mg/d效果更佳。
目的：分析不同劑量阿託伐他汀鈣治療動脈粥樣硬化性腦梗死的臨床效果及對血漿脂蛋白燐脂酶A2（Lp-PLA2）的影響。方法選取2013年12月~2014年10月本院確診收治的100例動脈粥樣硬化性腦梗死患者作為研究對象，隨機分為對照組和治療組，各50例。對照組患者給予常規治療+阿託伐他汀鈣10 mg/d治療，治療組患者給予常規治療+阿託伐他汀鈣40 mg/d治療。觀察兩組患者的臨床治療效果、血脂、炎癥因子Lp-PLA2變化情況，併作對比分析。結果治療組治療後的血脂、Lp-PLA2水平改善優于對照組（P<0.05）；治療組的總有效率為84%，明顯高于對照組的66%，差異有統計學意義（P<0.05）；兩組無嚴重不良反應。結論阿託伐他汀鈣治療動脈粥樣硬化性腦梗死，不僅能常規調節血脂水平，還能降低炎癥因子Lp-PLA2的水平，有較好的臨床效果，彊化治療40 mg/d效果更佳。
목적：분석불동제량아탁벌타정개치료동맥죽양경화성뇌경사적림상효과급대혈장지단백린지매A2（Lp-PLA2）적영향。방법선취2013년12월~2014년10월본원학진수치적100례동맥죽양경화성뇌경사환자작위연구대상，수궤분위대조조화치료조，각50례。대조조환자급여상규치료+아탁벌타정개10 mg/d치료，치료조환자급여상규치료+아탁벌타정개40 mg/d치료。관찰량조환자적림상치료효과、혈지、염증인자Lp-PLA2변화정황，병작대비분석。결과치료조치료후적혈지、Lp-PLA2수평개선우우대조조（P<0.05）；치료조적총유효솔위84%，명현고우대조조적66%，차이유통계학의의（P<0.05）；량조무엄중불량반응。결론아탁벌타정개치료동맥죽양경화성뇌경사，불부능상규조절혈지수평，환능강저염증인자Lp-PLA2적수평，유교호적림상효과，강화치료40 mg/d효과경가。
Objective To analyze clinical efficacy of atorvastatin calcium with different doses in the treatment of atherosclerotic cerebral infarction and its influence on plasma lipoprotein-associated phospholipase A2 (Lp-PLA2). Methods 100 patients definitely diagnosed as atherosclerotic cerebral infarction and admitted into our hospital from December 2013 to October 2014 were selected as research objects and evenly divided into control group and treatment group in random.Conventional therapy+atorvastatin calcium 10 mg/d were used in control group,conventional therapy+atorvastatin calcium 40 mg/d were used in treatment group.Clinical curative effect,blood lipids and change of inflamma-tory factor of Lp-PLA2 were observed and comparatively analyzed between two groups. Results Blood lipids and Lp-PLA2 level of treatment group was better than that of control group respectively(P<0.05).Total effective rate of treatment group was 84%,much higher than that in control group accounting for 66%,with significant difference (P<0.05).There was no obvious adverse reaction between two groups. Conclusion Atorvastatin calcium in the treatment of atheroscle-rotic cerebral infarction not only can reduce the level of blood lipids conventional,but also can reduce the Lp-PLA2 level of inflammatory factors,has a good clinical effect,strengthen the treatment of 40 mg/d is better.
