中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
12期
138-140
,共3页
肺炎克雷伯菌%小儿肠炎%多药耐药
肺炎剋雷伯菌%小兒腸炎%多藥耐藥
폐염극뢰백균%소인장염%다약내약
Klebsiella pneumoniae%Pediatric enteritis%Multi-drug resistance
目的：探讨多药耐药肺炎克雷伯菌引起小儿肠炎的临床特征、治疗问题以及药物试验，为今后临床实践提供参考和借鉴，以提高早期对其的鉴别和治疗。方法选择2012年1月~2014年1月本院收集的52例经粪便细菌培养证实的高产头孢菌素酶（AmpC）和产超广谱β-内酰胺酶（ESBLs）多药耐药肺炎克雷伯菌引起小儿肠炎的患者为研究对象，根据其临床资料进行回顾性分析和总结，探讨多药耐药肺炎克雷伯菌引起小儿肠炎的临床特征及治疗问题等。结果52例多药耐药肺炎克雷伯菌引起小儿肠炎的患者均与抗菌药物的不合理应用有关，通过给予合理的治疗后康复出院；多药耐药肺炎克雷伯菌对大多数的头孢菌素类抗菌药物产生耐药性，对亚胺培南的敏感性为100.0%。结论多药耐药肺炎克雷伯菌是引起小儿肠炎发生的重要病菌之一，年龄<2岁的小儿容易发生慢性腹泻等，治疗方式应以调节肠道微生态平衡为主，给予维生素B族等对症治疗措施，促进患儿尽快恢复健康。
目的：探討多藥耐藥肺炎剋雷伯菌引起小兒腸炎的臨床特徵、治療問題以及藥物試驗，為今後臨床實踐提供參攷和藉鑒，以提高早期對其的鑒彆和治療。方法選擇2012年1月~2014年1月本院收集的52例經糞便細菌培養證實的高產頭孢菌素酶（AmpC）和產超廣譜β-內酰胺酶（ESBLs）多藥耐藥肺炎剋雷伯菌引起小兒腸炎的患者為研究對象，根據其臨床資料進行迴顧性分析和總結，探討多藥耐藥肺炎剋雷伯菌引起小兒腸炎的臨床特徵及治療問題等。結果52例多藥耐藥肺炎剋雷伯菌引起小兒腸炎的患者均與抗菌藥物的不閤理應用有關，通過給予閤理的治療後康複齣院；多藥耐藥肺炎剋雷伯菌對大多數的頭孢菌素類抗菌藥物產生耐藥性，對亞胺培南的敏感性為100.0%。結論多藥耐藥肺炎剋雷伯菌是引起小兒腸炎髮生的重要病菌之一，年齡<2歲的小兒容易髮生慢性腹瀉等，治療方式應以調節腸道微生態平衡為主，給予維生素B族等對癥治療措施，促進患兒儘快恢複健康。
목적：탐토다약내약폐염극뢰백균인기소인장염적림상특정、치료문제이급약물시험，위금후림상실천제공삼고화차감，이제고조기대기적감별화치료。방법선택2012년1월~2014년1월본원수집적52례경분편세균배양증실적고산두포균소매（AmpC）화산초엄보β-내선알매（ESBLs）다약내약폐염극뢰백균인기소인장염적환자위연구대상，근거기림상자료진행회고성분석화총결，탐토다약내약폐염극뢰백균인기소인장염적림상특정급치료문제등。결과52례다약내약폐염극뢰백균인기소인장염적환자균여항균약물적불합리응용유관，통과급여합리적치료후강복출원；다약내약폐염극뢰백균대대다수적두포균소류항균약물산생내약성，대아알배남적민감성위100.0%。결론다약내약폐염극뢰백균시인기소인장염발생적중요병균지일，년령<2세적소인용역발생만성복사등，치료방식응이조절장도미생태평형위주，급여유생소B족등대증치료조시，촉진환인진쾌회복건강。
Objective To explore the clinical characteristics,treatment,and drug trial of pediatric enteritis induced by multi-drug resistance Klebsiella pneumoniae in order to provide a reference for clinical practices in future and improve its early identification and treatment. Methods 52 patients with pediatric enteritis caused by multi-drug resistance Klebsiella pneumoniae which was confirmed by AmpC enzyme and extended spectrum beta lactamase (ESBLs) from stool bacterial culture were selected as research objects.According to their clinical data,the clinical characteristics and treatment of pediatric enteritis caused by multi-drug resistance Klebsiella pneumoniae were retrospectively analyzed and summarized. Results 52 patients with pediatric enteritis resulted from multi-drug resistance Klebsiella pneumoniae were associated with irrational use of antimicrobial drugs,and they were recovered and discharged from hospital after providing with reasonable treatment.Multi-resistance Klebsiella pneumoniae was in drug resistance agalnst the majority of antimicrobial drugs in cephalosporins,and its sensitivity to imipenem was 100.0%. Conclusion Multi-drug resistance Klebsiella pneumoniae is one of the important pathogenic bacteria leading to the occurrence of pediatric enteritis.Chil-dren with the age less than 2 years old are vulnerable to chronic diarrhea,etc.The therapeutic method focuses on adjust-ing intestinal microecological balance as well as symptomatic treatment including vitamin B group so as to promote getting well as soon as possible.
