中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
12期
130-132,135
,共4页
肺部感染%降钙素原%C反应蛋白%诊断效能
肺部感染%降鈣素原%C反應蛋白%診斷效能
폐부감염%강개소원%C반응단백%진단효능
Pulmonary infection%Procalcitonin%C reactive protein%Diagnostic performance
目的：研究血清降钙素原（PCT）与C反应蛋白（CRP）联合检测诊断肺部细菌感染疾病的效能。方法将2012年8月~2014年9月本院收治的100例肺部细菌感染患者纳入研究的观察组，同期在本院体检的100例健康者纳入研究的对照组。检测两组受试者的血常规指标、PCT与CRP含量，观察肺部感染患者的咳嗽、咳痰缓解时间以及肺部啰音、胸片征象消失时间，比较血清PCT与CRP联合检测效能。结果观察组患者的PCT、CRP、白细胞计数、中性粒细胞比例均高于对照组[（14.33±1.94）ng/ml vs （2.19±0.34）ng/ml，（25.14±3.24）mg/L vs （7.52±0.91）mg/L，（15.28±1.94）×109/L vs （6.23±0.82）×109/L，（74.62±9.85）% vs （49.31±6.45）%]，差异有统计学意义（P<0.05）；血常规垣CRP垣PCT联合检测的灵敏度、特异度、准确度、阳性预测值、阴性预测值（94%、98%、96%、98.92%、94.23%）均明显高于血常规单独检测以及血常规垣CRP检测、血常规垣PCT检测；血清PCT、CRP含量与咳嗽、咳痰缓解时间以及肺部啰音、胸片征象消失时间呈正相关。结论血清PCT与CRP联合检测能够提高肺部细菌感染的诊断效能，且与临床症状和体征的缓解具有良好的相关性，是理想的辅助检查指标。
目的：研究血清降鈣素原（PCT）與C反應蛋白（CRP）聯閤檢測診斷肺部細菌感染疾病的效能。方法將2012年8月~2014年9月本院收治的100例肺部細菌感染患者納入研究的觀察組，同期在本院體檢的100例健康者納入研究的對照組。檢測兩組受試者的血常規指標、PCT與CRP含量，觀察肺部感染患者的咳嗽、咳痰緩解時間以及肺部啰音、胸片徵象消失時間，比較血清PCT與CRP聯閤檢測效能。結果觀察組患者的PCT、CRP、白細胞計數、中性粒細胞比例均高于對照組[（14.33±1.94）ng/ml vs （2.19±0.34）ng/ml，（25.14±3.24）mg/L vs （7.52±0.91）mg/L，（15.28±1.94）×109/L vs （6.23±0.82）×109/L，（74.62±9.85）% vs （49.31±6.45）%]，差異有統計學意義（P<0.05）；血常規垣CRP垣PCT聯閤檢測的靈敏度、特異度、準確度、暘性預測值、陰性預測值（94%、98%、96%、98.92%、94.23%）均明顯高于血常規單獨檢測以及血常規垣CRP檢測、血常規垣PCT檢測；血清PCT、CRP含量與咳嗽、咳痰緩解時間以及肺部啰音、胸片徵象消失時間呈正相關。結論血清PCT與CRP聯閤檢測能夠提高肺部細菌感染的診斷效能，且與臨床癥狀和體徵的緩解具有良好的相關性，是理想的輔助檢查指標。
목적：연구혈청강개소원（PCT）여C반응단백（CRP）연합검측진단폐부세균감염질병적효능。방법장2012년8월~2014년9월본원수치적100례폐부세균감염환자납입연구적관찰조，동기재본원체검적100례건강자납입연구적대조조。검측량조수시자적혈상규지표、PCT여CRP함량，관찰폐부감염환자적해수、해담완해시간이급폐부라음、흉편정상소실시간，비교혈청PCT여CRP연합검측효능。결과관찰조환자적PCT、CRP、백세포계수、중성립세포비례균고우대조조[（14.33±1.94）ng/ml vs （2.19±0.34）ng/ml，（25.14±3.24）mg/L vs （7.52±0.91）mg/L，（15.28±1.94）×109/L vs （6.23±0.82）×109/L，（74.62±9.85）% vs （49.31±6.45）%]，차이유통계학의의（P<0.05）；혈상규원CRP원PCT연합검측적령민도、특이도、준학도、양성예측치、음성예측치（94%、98%、96%、98.92%、94.23%）균명현고우혈상규단독검측이급혈상규원CRP검측、혈상규원PCT검측；혈청PCT、CRP함량여해수、해담완해시간이급폐부라음、흉편정상소실시간정정상관。결론혈청PCT여CRP연합검측능구제고폐부세균감염적진단효능，차여림상증상화체정적완해구유량호적상관성，시이상적보조검사지표。
Objective To study the value of serum procalcitonin (PCT) and C reactive protein (CRP) combination detec-tion in diagnosing pulmonary infection. Methods 100 cases of patients with pulmonary bacterial infection in our hospi-tal from August 2012 to September 2014 were enrolled in observation group,100 cases of health subjects received health examination at the same period were enrolled in control group.Then blood routine index,serum PCT,CRP level was detected;cough,expectoration remission time,pulmonary rales and chest X-ray signs disappeared time was observed, serum PCT and CRP combined detection efficiency was compared. Results The serum PCT,CRP level,white blood cell count,neutrophile granulocyte ratio in observation group was higher than that in control group [(14.33±1.94) ng/ml vs (2.19±0.34) ng/ml,(25.14±3.24) mg/L vs (7.52±0.91) mg/L,(15.28±1.94)í109/L vs (6.23±0.82)í109/L,(74.62±9.85)% vs (49.31±6.45)%],the difference was significant (P<0.05).The sensitivity,specific,accuracy,positive predictive value,nega-tive predictive value of blood routine+CRP+PCT detection (94%,98%,96%,98.92%,94.23%) was higher than that of blood routine detection,blood routine+CRP detection and blood routine+PCT detection.The level of procalcitonin was positively correlated with cough, sputum, asthma,pulmonary rales remission time. Conclusion Combination detection of serum PCT and CRP is an ideal auxiliary examination index for it can improve the sensitivity and specificity of bacteria infection diagnosis and has a good correlation with clinical symptoms and signs.
