中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
4期
526-528
,共3页
氯氮平%血药浓度%监测%构成比%分析
氯氮平%血藥濃度%鑑測%構成比%分析
록담평%혈약농도%감측%구성비%분석
Clozapine%Blood concentration%Monitor%Constituent ratio%Analysis
目的：分析梅州市第三人民医院2012—2014年服用氯氮平的182例精神分裂症患者的血药浓度与疗效、不良反应的关系，为临床合理用药提供科学依据。方法：采用回顾性方法，利用Microsoft Excel电子表格统计患者年龄、性别、服药剂量、联合用药、各项检查结果、疗效及不良反应。查阅相关的文献资料进行综合分析评价。结果：该院开展血药浓度监测情况不理想，行血药浓度检测的90．00％是住院患者。182例监测数据中，59．90％在有效血药浓度范围内。只监测1次血药浓度的患者显效80例，占67．23％；通过血药浓度监测调整剂量并进行多次监测的显效54例，占85．71％。结论：应加大血药浓度监测的宣传。临床使用氯氮平时，应监测氯氮平的血药浓度，及时调整氯氮平的给药剂量，制订个体化的给药方案。
目的：分析梅州市第三人民醫院2012—2014年服用氯氮平的182例精神分裂癥患者的血藥濃度與療效、不良反應的關繫，為臨床閤理用藥提供科學依據。方法：採用迴顧性方法，利用Microsoft Excel電子錶格統計患者年齡、性彆、服藥劑量、聯閤用藥、各項檢查結果、療效及不良反應。查閱相關的文獻資料進行綜閤分析評價。結果：該院開展血藥濃度鑑測情況不理想，行血藥濃度檢測的90．00％是住院患者。182例鑑測數據中，59．90％在有效血藥濃度範圍內。隻鑑測1次血藥濃度的患者顯效80例，佔67．23％；通過血藥濃度鑑測調整劑量併進行多次鑑測的顯效54例，佔85．71％。結論：應加大血藥濃度鑑測的宣傳。臨床使用氯氮平時，應鑑測氯氮平的血藥濃度，及時調整氯氮平的給藥劑量，製訂箇體化的給藥方案。
목적：분석매주시제삼인민의원2012—2014년복용록담평적182례정신분렬증환자적혈약농도여료효、불량반응적관계，위림상합리용약제공과학의거。방법：채용회고성방법，이용Microsoft Excel전자표격통계환자년령、성별、복약제량、연합용약、각항검사결과、료효급불량반응。사열상관적문헌자료진행종합분석평개。결과：해원개전혈약농도감측정황불이상，행혈약농도검측적90．00％시주원환자。182례감측수거중，59．90％재유효혈약농도범위내。지감측1차혈약농도적환자현효80례，점67．23％；통과혈약농도감측조정제량병진행다차감측적현효54례，점85．71％。결론：응가대혈약농도감측적선전。림상사용록담평시，응감측록담평적혈약농도，급시조정록담평적급약제량，제정개체화적급약방안。
OBJECTIVE:To analyze the relationship between blood concentration and curative efficacy and adverse drug reactions in 182 patients with schizophrenia receiving clozapine in Meizhou Municipal Third People's Hospital during 2012-2014 period so as to provide scientific basis for clinical rational use of drug.METHODS: By using the retrospective method, the data including patients'age, sex, dosage of clozapine administered, drug combination, laboratory tests, curative efficacy and adverse drug reaction were analyzed statistically using Microsoft Excel.The relevant literature data were reviewed and a comprehensive analysis and evaluation was performed.RESULTS: The blood concentration monitoring in our hospital was far from ideal.Of all the patients receiving blood concentration monitoring, 90.00%were inpatients.The blood concentration in 59.90%of the total 182 monitoring cases was within the effective range; 67.23% receiving blood concentration monitoring for only once.54 cases ( 85.71%) showed excellent clinical response due to frequent blood concentration monitoring and dosage adjustment.CONCLUSION:We should strengthen the publicity of the blood concentration monitoring.Blood concentration monitoring should be performed during its clinical use, so as to adjust its dosage timely and develop individualized dosage regimen.
