CAJ | 학술논문

目的：了解硫酸镍斑贴试验不同结果对L??a??b??色度系统变化的影响。方法：对38名健康志愿者进行人体皮肤封闭型硫酸镍斑贴试验。将2.5%硫酸镍斑试器用胶带贴敷在受试者上背部，同时设空白对照，封包24h后揭去斑试物。分别于试验前（D0）、揭去斑试物后0.5h(D1)、24h(D2)对皮肤反应结果进行临床评估及皮肤颜色L??a??b??值测定。结果：38例受试者中8例在D1和（或）D2时临床评估为阳性。镍斑贴试验阴性组、空白对照组受试者D1、D2时皮肤色度L??值、b??值及a??值较D0均无明显变化；斑贴试验阳性组D1、D2时皮肤色度a??值分别为10.64±1.90和13.22±1.92，较D0时皮肤色度a??值7.80±2.49明显升高（P=0.000）。结论：硫酸镍斑贴诱发的接触性皮炎模型中，L??a??b??色度系统a??值能反映皮肤发生炎症后的红斑变化，可作为评估接触性皮炎的客观评价参数。
목적：료해류산얼반첩시험불동결과대L??a??b??색도계통변화적영향。방법：대38명건강지원자진행인체피부봉폐형류산얼반첩시험。장2.5%류산얼반시기용효대첩부재수시자상배부，동시설공백대조，봉포24h후게거반시물。분별우시험전（D0）、게거반시물후0.5h(D1)、24h(D2)대피부반응결과진행림상평고급피부안색L??a??b??치측정。결과：38례수시자중8례재D1화（혹）D2시림상평고위양성。얼반첩시험음성조、공백대조조수시자D1、D2시피부색도L??치、b??치급a??치교D0균무명현변화；반첩시험양성조D1、D2시피부색도a??치분별위10.64±1.90화13.22±1.92，교D0시피부색도a??치7.80±2.49명현승고（P=0.000）。결론：류산얼반첩유발적접촉성피염모형중，L??a??b??색도계통a??치능반영피부발생염증후적홍반변화，가작위평고접촉성피염적객관평개삼수。
Objective To understand the effects of the different results of nickel sulfate patch test on the L*a *b *chromatic system. Methods The occlusive human nickel sulfate patch test was in 38 healthy volunteers.The 2.5%nickel sulfate patch test was tapped on the back of the volunteers for 24 hours.Measurements including clinical evaluation and the determination of L*a *b *were made before patch occlusion and 0.5h(D1),24h(D2) after patch removal, respectively. Results In all 38 subjects, 8 cases were judged positive at D1 and (or) D2.There was no significant difference between positive group an negative group in the values of L**b *and a*at D1 and D2. The a*values of positive goup at D1, D2 were 10.64±1.90,13.22±1.92 respectively, which both were higher than the value 7.80±2.49 before patch test (P=0.000). Conclusion In the contact dermatitis model inducing by nickel sulfate, the a*val?ue of the L*a *b *chromatic system can reflect erythematic changes after skin inflammation, showing a*value maybe the objective evaluation parameter to evaluate contact dermatitis.