CAJ | 학술논문

目的：对比分析应用齐拉西酮与利培酮治疗女性精神分裂症患者时对催乳素(PRL)水平的影响。方法选取我院2014年1~10月期间住院治疗的250例女性精神分裂症患者作为临床研究对象，按随机数字表法将其随机分为齐拉西酮组和利培酮组，齐拉西酮组服用齐拉西酮，利培酮组服用利培酮。服药前对患者的催乳素水平进行检测，自服药后，从第4周开始，每隔2周检测1次患者的血清 PRL 水平，比较两组患者 PRL 的水平差异。结果两组患者治疗前的血清 PRL 水平差异无统计学意义(P >0.05)，治疗后第4周末，两组患者 PRL 水平较服药前的 PRL 水平均有增加，但差异无统计学意义；但第6、8、10周末时，齐拉西酮组的患者 PRL 水平趋于平稳，利培酮组的患者 PRL 水平继续增加，两组 PRL 水平对比差异均有统计学意义(P <0.05)。齐拉西酮组不良反应发生率为16.80%；利培酮组不良反应发生率为31.20%，差异具有统计学意义(P <0.01)。结论服用利培酮治疗女性精神分裂症时，对患者 PRL 水平的影响大且并发症发生率高，而齐拉西酮治疗女性精神分裂症时，对患者 PRL 水平影响较小，而且不良反应发生率低，值得临床推广使用。
목적：대비분석응용제랍서동여리배동치료녀성정신분렬증환자시대최유소(PRL)수평적영향。방법선취아원2014년1~10월기간주원치료적250례녀성정신분렬증환자작위림상연구대상，안수궤수자표법장기수궤분위제랍서동조화리배동조，제랍서동조복용제랍서동，리배동조복용리배동。복약전대환자적최유소수평진행검측，자복약후，종제4주개시，매격2주검측1차환자적혈청 PRL 수평，비교량조환자 PRL 적수평차이。결과량조환자치료전적혈청 PRL 수평차이무통계학의의(P >0.05)，치료후제4주말，량조환자 PRL 수평교복약전적 PRL 수평균유증가，단차이무통계학의의；단제6、8、10주말시，제랍서동조적환자 PRL 수평추우평은，리배동조적환자 PRL 수평계속증가，량조 PRL 수평대비차이균유통계학의의(P <0.05)。제랍서동조불량반응발생솔위16.80%；리배동조불량반응발생솔위31.20%，차이구유통계학의의(P <0.01)。결론복용리배동치료녀성정신분렬증시，대환자 PRL 수평적영향대차병발증발생솔고，이제랍서동치료녀성정신분렬증시，대환자 PRL 수평영향교소，이차불량반응발생솔저，치득림상추엄사용。
Objective To compare the effects of ziprasidone and risperidone on prolactin (PRL)levels in female patients with schizophrenia. Methods A total of 250 female cases with schizophrenia were included in the study from January 2014 to October 2014 cared at our hospital.According to the random number table,the cases were divided into a ziprasidone group and a risperidone group.Ziprasidone group used ziprasidone,and the risperidone group used risperidone.The prolactin levels were determined before treatment.From the be-ginning of the fourth week,the prolactin levels of patients were determined every two weeks.The prolactin levels were compared in two groups. Results Group-paired comparison of the ore- treatment prolactin lev-els yielded no statistically significant difference (P >0.05).At the end of the fourth week after treatment,the PRL levels of two groups both increased,but compared to pre-treatment,there was no statistically significant difference (P >0.05).At the ends of the sixth,the eighth,the tenth weeks after treatment,the PRL level of ziprasidone group was tended to be stable,the PRL level of risperidone group continued to increase,group-paired comparison yielded statistically significant differences (P <0.05).The adverse reactions rate of ziprasi-done group was 17.86%,significantly higher than that of the risperidone group’s 31.20%,group - paired comparison yielded statistically significant difference (P <0.05). Conclusion Risperidone in treatment of patients with schizophrenia had more effects on the PRL level than ziprasidone,and the adverse reactions rate of patients was higher than ziprasidone.And Ziprasidone had less effects on the PRL and less adverse reaction rate,Ziprasidone is worthy of clinical recommendation.