中国美容医学
中國美容醫學
중국미용의학
CHINESE JOURNAL OF AESTHETIC MEDICINE
2015年
8期
44-46
,共3页
奥昔康唑%特比萘芬%甲真菌病%疗效
奧昔康唑%特比萘芬%甲真菌病%療效
오석강서%특비내분%갑진균병%료효
Oxiconazole%Terbinafine%onychomycosis%curative observation
目的：观察奥昔康唑联合特比萘芬治疗甲真菌病的疗效。方法：选取2012年7月-2014年8月就诊的患有甲真菌病的90例患者，随机分为A、B、C三组，每组30例。A组：采用硝酸奥昔康唑乳膏外涂，每天2次，连用12周；B组采用盐酸特比萘芬片口服，0.25g/d，连用12周；C组采用硝酸奥昔康唑乳膏外涂，每天2次，同时口服盐酸特比萘芬片，0.25g/d，两种药物连用12周。依据SCIO 评分，观察治疗全程中的疗效及不良反应。结果：连用12周后，A组总有效率70.0%，B组66.7%,C组90.0%，C组总有效率明显高于A、B两组，具有统计学意义（P＜0.05）。不良反应中，A组外用硝酸奥昔康唑软膏时有3例患者先后发生瘙痒、轻度烧灼感；B组口服盐酸特比萘芬片过程中有4例患者先后出现胃肠道反应、皮疹；C组联合用药，有4例患者先后发生瘙痒、轻度烧灼感，有6例患者先后出现胃肠道反应、皮疹。三组患者不良反应均为轻微或一过性反应，无统计学意义（P＞0.05）。结论：硝酸奥昔康唑乳膏联合盐酸特比萘芬片治疗甲真菌病比单一用药疗效更为肯定，可临床推广应用。
目的：觀察奧昔康唑聯閤特比萘芬治療甲真菌病的療效。方法：選取2012年7月-2014年8月就診的患有甲真菌病的90例患者，隨機分為A、B、C三組，每組30例。A組：採用硝痠奧昔康唑乳膏外塗，每天2次，連用12週；B組採用鹽痠特比萘芬片口服，0.25g/d，連用12週；C組採用硝痠奧昔康唑乳膏外塗，每天2次，同時口服鹽痠特比萘芬片，0.25g/d，兩種藥物連用12週。依據SCIO 評分，觀察治療全程中的療效及不良反應。結果：連用12週後，A組總有效率70.0%，B組66.7%,C組90.0%，C組總有效率明顯高于A、B兩組，具有統計學意義（P＜0.05）。不良反應中，A組外用硝痠奧昔康唑軟膏時有3例患者先後髮生瘙癢、輕度燒灼感；B組口服鹽痠特比萘芬片過程中有4例患者先後齣現胃腸道反應、皮疹；C組聯閤用藥，有4例患者先後髮生瘙癢、輕度燒灼感，有6例患者先後齣現胃腸道反應、皮疹。三組患者不良反應均為輕微或一過性反應，無統計學意義（P＞0.05）。結論：硝痠奧昔康唑乳膏聯閤鹽痠特比萘芬片治療甲真菌病比單一用藥療效更為肯定，可臨床推廣應用。
목적：관찰오석강서연합특비내분치료갑진균병적료효。방법：선취2012년7월-2014년8월취진적환유갑진균병적90례환자，수궤분위A、B、C삼조，매조30례。A조：채용초산오석강서유고외도，매천2차，련용12주；B조채용염산특비내분편구복，0.25g/d，련용12주；C조채용초산오석강서유고외도，매천2차，동시구복염산특비내분편，0.25g/d，량충약물련용12주。의거SCIO 평분，관찰치료전정중적료효급불량반응。결과：련용12주후，A조총유효솔70.0%，B조66.7%,C조90.0%，C조총유효솔명현고우A、B량조，구유통계학의의（P＜0.05）。불량반응중，A조외용초산오석강서연고시유3례환자선후발생소양、경도소작감；B조구복염산특비내분편과정중유4례환자선후출현위장도반응、피진；C조연합용약，유4례환자선후발생소양、경도소작감，유6례환자선후출현위장도반응、피진。삼조환자불량반응균위경미혹일과성반응，무통계학의의（P＞0.05）。결론：초산오석강서유고연합염산특비내분편치료갑진균병비단일용약료효경위긍정，가림상추엄응용。
Objective Observation of the curative effect of Oxiconazole combined with Terbinafine for the treatment of onychomycosis. Methods 90 patients with onychomycosis were randomly divided into 3 groups,each group consisted of 30 patients.Group A was treated Oxiconazole Cream,two times a day for 12 weeks.Group B took Terbinafine Tablets,0.25g/d for 12 weeks. Group C was treated by topical and oral simultaneously.According to SCIO score, observed the curative effect and adverse re?action in the treatment. Results A group’s total efficiency was 70.0% after 12 weeks,B was 66.7%, and C was 90.0%.There were significant differences between A and B,C(P<0.05).The adverse reac?tion,Group A had 3 cases occurred itching,mild burning sensation.Group B had 4 patients appeared gastrointestinal reaction, rash. In Group C,4 cases had occurred itching,mild burning sensation,6 cas?es had appeared gastrointestinal reaction, rash. There was no statistical significance between the three groups(P>0.05). Conclusion It has more effective to treat onychomycosis with Oxiconazole combined with Terbinafine.
