CAJ | 학술논문

目的：探讨分析乌司他丁联合生长抑素治疗重症急性胰腺炎(SAP)患者的临床疗效。方法选取84例 SAP患者随机分为观察组和对照组，对照组给予常规治疗(禁食、肠胃持续减压等)+乌司他丁注射液；观察组用与对照组相同的治疗方案，另加生长抑素。比较两组患者临床疗效、临床症状恢复时间、TNF-α和 IL-6水平及不良反应发生情况。结果观察组患者临床疗效有效率高于对照组患者，治疗后 TNF-α和 IL-6水平改善优于对照组患者，淀粉酶恢复时间、尿淀粉酶恢复时间、腹痛缓解时间、腹水消退时间较对照组患者显著缩短，差异均具有统计学意义(P <0.001)。结论乌司他丁联合生长抑制素治疗 SAP 临床疗效高，恢复时间显著缩短，安全可靠，值得在临床上进一步推广应用。
목적：탐토분석오사타정연합생장억소치료중증급성이선염(SAP)환자적림상료효。방법선취84례 SAP환자수궤분위관찰조화대조조，대조조급여상규치료(금식、장위지속감압등)+오사타정주사액；관찰조용여대조조상동적치료방안，령가생장억소。비교량조환자림상료효、림상증상회복시간、TNF-α화 IL-6수평급불량반응발생정황。결과관찰조환자림상료효유효솔고우대조조환자，치료후 TNF-α화 IL-6수평개선우우대조조환자，정분매회복시간、뇨정분매회복시간、복통완해시간、복수소퇴시간교대조조환자현저축단，차이균구유통계학의의(P <0.001)。결론오사타정연합생장억제소치료 SAP 림상료효고，회복시간현저축단，안전가고，치득재림상상진일보추엄응용。
Objective To investigate the effectiveness of Ulinastatin combined with somatostatin in treat-ment of patients with severe acute pancreatitis (SAP). Methods Eighty-four cases of SAP patients were randomly divided into two groups.The control group was given traditional treatment (fasting,continuous gas-trointestinal decompression,etc.)combined with ulinastatin injection,and the experimental group was treated with the same therapy as the control group,plus somatostatin.The clinical curative efficacy,recovery time of clinical symptoms,levels of TNF-α and IL-6,and the incidence of adverse reactions were observed in the two groups of patients. Results Compared to the control group,the effective rates was higher and the im-provement of post-treatment TNF-α and IL-6 levels was better for the experimental group.The time of amylase recovery,urine amylase recovery,abdominal pain relief,ascites subsidise in experimental group were significantly shorter than those in the control group (P <0.001 ). Conclusion The results suggested the combination drug treatment facilitated the improvement of SAP,shortened the recovery time,and was safe, reliable,worthy of further application in clinical practice.