CAJ | 학술논문

目的：探讨银杏达莫联合辛伐他汀对急性脑梗死的疗效及血液指标的影响。方法随机选择2012年6月~2014年6月本院诊治的112例急性脑梗死患者，随机分为两组，对照组56例患者给予常规治疗，研究组56例患者给予常规治疗基础上再予以银杏达莫联合辛伐他汀治疗，采用美国国立卫生院卒中量表(NIHSS)评分判定神经功能缺损情况，比较两组 NIHSS 得分、血液指标改善情况以及用药不良反应。结果两组患者经治疗后 NIHSS 评分及血液指标(TC、TG、Hct 等)与治疗前比较差异均具有统计学意义(P <0.05或 P <0.01)，而研究组上述各项指标改善情况更为显著，且优于对照组治疗后，组间比较差异均具有统计学意义(P <0.05或 P <0.01)；两组用药后均未见严重不良反应。结论银杏达莫联合辛伐他汀对急性脑梗死疗效及血液指标均具有积极影响，且安全性较高，具有临床实际应用价值。
목적：탐토은행체막연합신벌타정대급성뇌경사적료효급혈액지표적영향。방법수궤선택2012년6월~2014년6월본원진치적112례급성뇌경사환자，수궤분위량조，대조조56례환자급여상규치료，연구조56례환자급여상규치료기출상재여이은행체막연합신벌타정치료，채용미국국립위생원졸중량표(NIHSS)평분판정신경공능결손정황，비교량조 NIHSS 득분、혈액지표개선정황이급용약불량반응。결과량조환자경치료후 NIHSS 평분급혈액지표(TC、TG、Hct 등)여치료전비교차이균구유통계학의의(P <0.05혹 P <0.01)，이연구조상술각항지표개선정황경위현저，차우우대조조치료후，조간비교차이균구유통계학의의(P <0.05혹 P <0.01)；량조용약후균미견엄중불량반응。결론은행체막연합신벌타정대급성뇌경사료효급혈액지표균구유적겁영향，차안전성교고，구유림상실제응용개치。
Objective To explore the curative effect of Yinxing Damo (an injection containing Ginko leaf extract and dipyridamole)combined with Simvastatin for the treatment of acute cerebral infarction and the effects on blood index. Methods The data of 1 12 patients with acute cerebral infarction were randomly se-lected from those who had received treatment in our hospital from June 2013 to June 2014,and the patients were randomly divided into two groups.While the 56 cases in the control group were given conventional treat-ment,the 56 cases in the study group were given conventional treatment plus YinxingDamo combined with Simvastatin.The nerve function defects were evaluated by using National Institute of Health Stroke Scale (NIHSS);and the group-comparison of NIHSS scores,changes of the blood index and drug adverse reactions in both groups was done. Results Post-treatment NIHSS score and blood indexes (such as TC,TG and Hct)for both groups were significantly improved than pre-treatment,and the intra-group comparison yiel-ded statistically differences (P <0.05 or P <0.01).Moreover,the improvement on the above indexes in the study group was more obvious,and were better than those of the control group after treatment,the group-paired comparison showed statistically differences (P <0.05 or P <0.01 ).Besides,after the treatment,no serious adverse reactions occurred in both groups. Conclusion YinxingDamo combined with Simvastatin is of effective for the treatment of acute cerebral infarction and for the improvement of blood index,and it is more safe,thus,worthwhile to be clinical use.