CAJ | 학술논문

目的：探讨缬沙坦联合非洛地平治疗高血压的临床应用效果。方法选取2010年11月~2012年11月于我院治疗原发性高血压患者350例。根据随机数字法均分为治疗组和对照组各175例，治疗组患者采用缬沙坦联合非洛地平，对照组患者采用非洛地平单一给药，对比两组患者治疗效果。结果对照组患者治疗有效率为73.99%，治疗组患者治疗有效率为92.00%，效果明显优于对照组患者(P <0.001)；治疗组采用联合用药后，舒张压和收缩压的降低程度均显著优于对照组患者(P <0.001)。结论缬沙坦联合非洛地平是一种较为有效的临床治疗高血压的用药方案，该方法治疗效果显著，患者临床血压控制理想，无明显不良反应。
목적：탐토힐사탄연합비락지평치료고혈압적림상응용효과。방법선취2010년11월~2012년11월우아원치료원발성고혈압환자350례。근거수궤수자법균분위치료조화대조조각175례，치료조환자채용힐사탄연합비락지평，대조조환자채용비락지평단일급약，대비량조환자치료효과。결과대조조환자치료유효솔위73.99%，치료조환자치료유효솔위92.00%，효과명현우우대조조환자(P <0.001)；치료조채용연합용약후，서장압화수축압적강저정도균현저우우대조조환자(P <0.001)。결론힐사탄연합비락지평시일충교위유효적림상치료고혈압적용약방안，해방법치료효과현저，환자림상혈압공제이상，무명현불량반응。
Objective To explore the clinical application effect of valsartan combined with felodipine on hypertension. Methods A total of 350 cases of hypertension patients cared at our hospital from November 2010 to November 2012,were randomly divided into two groups.Patients in the treatment group (175 cases) were treated with valsartan and felodipine,whereas patients in the control group(175 cases)were treated with single felodipine.The effective rate was observed in the two groups. Results The effective rates in the con-trol and treatment group were 73.99% and 92.00%,respectively.The effect of the treatment group was more favorable than the control group (P < 0.001 ).Reduction in the diastolic blood pressure and systolic blood pressure in the combination drug treatment group was superior to those in the control group(P <0.001). Conclusion The results indicated that the combination of valsartan and felodipine was an effective management strategy for hypertension and greatly improved the clinical efficacy for hypertension patients.The blood pres-sure was perfectly controlled with no obvious adverse reactions by the combination drug treatment.