CAJ | 학술논문

目的：探讨降钙素原对自身免疫性疾病（autoimmune disease，AID）患者合并细菌感染的诊断价值。方法检测181例确诊 AID 患者的降钙素原（procalcitonin，PCT）、C 反应蛋白（C －reaction protein，CRP）、红细胞沉降率（erythro-cyte sedimentation rate，ESR）及白细胞计数，比较上述指标诊断细菌感染的敏感性及特异性，评价 PCT 对于细菌感染的诊断价值。结果AID 患者合并细菌感染组 PCT、CRP 较非感染组高（P ＜0．05），两组 WBC 和 ESR 差异无统计学意义（P ＞0．05），ROC 曲线提示 PCT 诊断 AID 合并细菌感染具有更高的特异性和敏感性。病情稳定的 SLE 合并细菌感染组PCT、CRP 均高于非感染组（P ＜0．05），ROC 曲线提示 CRP 诊断病情稳定的 SLE 合并细菌感染的特异性和敏感性高于PCT。结论PCT 在 AID 合并细菌感染中具有诊断价值，并受疾病种类及病情活动度影响。
목적：탐토강개소원대자신면역성질병（autoimmune disease，AID）환자합병세균감염적진단개치。방법검측181례학진 AID 환자적강개소원（procalcitonin，PCT）、C 반응단백（C －reaction protein，CRP）、홍세포침강솔（erythro-cyte sedimentation rate，ESR）급백세포계수，비교상술지표진단세균감염적민감성급특이성，평개 PCT 대우세균감염적진단개치。결과AID 환자합병세균감염조 PCT、CRP 교비감염조고（P ＜0．05），량조 WBC 화 ESR 차이무통계학의의（P ＞0．05），ROC 곡선제시 PCT 진단 AID 합병세균감염구유경고적특이성화민감성。병정은정적 SLE 합병세균감염조PCT、CRP 균고우비감염조（P ＜0．05），ROC 곡선제시 CRP 진단병정은정적 SLE 합병세균감염적특이성화민감성고우PCT。결론PCT 재 AID 합병세균감염중구유진단개치，병수질병충류급병정활동도영향。
Objective To evaluate the value of PCT in diagnosis of bacterial infection in patients with autoimmune disease. Methods 181 AID patients were enrolled into this study.The levels of PCT,CRP,ESR and WBC were detected by routine ex-perimental protocols.The sensitivity and specificity of these indexes in diagnosis of bacterial infection in patients with autoim-mune disease were compared.Results In patients with AID,the levels of PCT and CRP in bacterial infection group were much higher than that in the non -infection group(P <0.05).However,when it came to WBC and ESR,there were no significant differences between two groups (P >0.05).The ROC showed that PCT had a better sensitivity and specificity in diagnosis of bacterial infection in AID patients.While in non -active SLE patients,CRP had a better sensitivity and specificity in diagnosis of bacterial infection according to the ROC.Conclusion Elevated PCT levels had a good diagnostic value for infection in pa-tients with AID,and it differs in different diseases and disease activity.