中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
4期
450-452
,共3页
金水宝%贝那普利%糖尿病%蛋白尿
金水寶%貝那普利%糖尿病%蛋白尿
금수보%패나보리%당뇨병%단백뇨
Jinshuibao%Benazepril%Diabetes%Proteinuria
目的：探讨金水宝联合贝那普利治疗糖尿病肾病蛋白尿的临床效果。方法：选取广州市番禺区何贤纪念医院2011年6月至2013年5月收治的100例糖尿病肾病患者，随机分为对照组和观察组，各50例。对照组仅采用贝那普利治疗，观察组采用金水宝联合贝那普利治疗，比较两组患者治疗前后24 h尿蛋白含量、24 h尿微量清蛋白排泄率、血肌酐以及尿素氮的变化，同时评价两组不良反应和治疗满意度情况。结果：治疗后，两组患者24 h尿蛋白含量、24 h尿微量清蛋白排泄率、血肌酐均降低，观察组较对照组降低更显著，差异均具有统计学意义（均P＜0．05）；治疗前后，尿素氮水平无显著变化，两组间差异无统计学意义。两组均未发生严重不良反应，观察组不良反应发生率（8．0％）略低于对照组（10．0％），差异无统计学意义；观察组治疗满意度（96．0％）显著高于对照组（72．0％），差异具有统计学意义，P＜0．05。结论：金水宝联合贝那普利能显著改善糖尿病患者尿蛋白水平，两者疗效互补，且无严重不良反应，治疗满意度高，值得临床推广使用。
目的：探討金水寶聯閤貝那普利治療糖尿病腎病蛋白尿的臨床效果。方法：選取廣州市番禺區何賢紀唸醫院2011年6月至2013年5月收治的100例糖尿病腎病患者，隨機分為對照組和觀察組，各50例。對照組僅採用貝那普利治療，觀察組採用金水寶聯閤貝那普利治療，比較兩組患者治療前後24 h尿蛋白含量、24 h尿微量清蛋白排洩率、血肌酐以及尿素氮的變化，同時評價兩組不良反應和治療滿意度情況。結果：治療後，兩組患者24 h尿蛋白含量、24 h尿微量清蛋白排洩率、血肌酐均降低，觀察組較對照組降低更顯著，差異均具有統計學意義（均P＜0．05）；治療前後，尿素氮水平無顯著變化，兩組間差異無統計學意義。兩組均未髮生嚴重不良反應，觀察組不良反應髮生率（8．0％）略低于對照組（10．0％），差異無統計學意義；觀察組治療滿意度（96．0％）顯著高于對照組（72．0％），差異具有統計學意義，P＜0．05。結論：金水寶聯閤貝那普利能顯著改善糖尿病患者尿蛋白水平，兩者療效互補，且無嚴重不良反應，治療滿意度高，值得臨床推廣使用。
목적：탐토금수보연합패나보리치료당뇨병신병단백뇨적림상효과。방법：선취엄주시번우구하현기념의원2011년6월지2013년5월수치적100례당뇨병신병환자，수궤분위대조조화관찰조，각50례。대조조부채용패나보리치료，관찰조채용금수보연합패나보리치료，비교량조환자치료전후24 h뇨단백함량、24 h뇨미량청단백배설솔、혈기항이급뇨소담적변화，동시평개량조불량반응화치료만의도정황。결과：치료후，량조환자24 h뇨단백함량、24 h뇨미량청단백배설솔、혈기항균강저，관찰조교대조조강저경현저，차이균구유통계학의의（균P＜0．05）；치료전후，뇨소담수평무현저변화，량조간차이무통계학의의。량조균미발생엄중불량반응，관찰조불량반응발생솔（8．0％）략저우대조조（10．0％），차이무통계학의의；관찰조치료만의도（96．0％）현저고우대조조（72．0％），차이구유통계학의의，P＜0．05。결론：금수보연합패나보리능현저개선당뇨병환자뇨단백수평，량자료효호보，차무엄중불량반응，치료만의도고，치득림상추엄사용。
OBJECTIVE:To investigate the effect of Jinshuibao plus benazepril on proteinuria in patients with diabetic nephropathy.METHODS:100 patients with diabetic nephropathy admitted to Guangzhou Panyu District Hexian Memorial Hospital from June 2011-May 2013 were randomly assigned to either control group treated with benazepril alone or observation group treated with Jinshuibao plus benazepril.The 24-hour urine protein, urine microalbumin excretion rate, serum creatinine and urea nitrogen levels before and after treatment were compared between the two groups, meanwhile, the adverse drug reactions and patients'satisfaction degree to treatment were evaluated.RESULTS:After treatment, the 24-hour urine protein, urine microalbumin excretion rate, serum creatinine and urea nitrogen levels decreased in both groups, much as in the observation group, and the difference was statistically significant between the two groups ( P <0.05 ); after treatment, no significant change was noted in urea nitrogen level in both groups and the difference between the two groups were insignificant (P<0.05);neither group showed serious adverse drug reaction (ADR), and the ADR occurred slightly yet insignificantly less frequent in the observation group than in the control group;the rate of patients who were satisfied toward treatment in observation group was significantly higher than in the control group (96.0% vs.72.0%), and the difference was statistically significant (P<0.05).CONCLUSION: Addition of Jinshuibao to benazepril in treatment of patients with diabetes resulted in significant improvement in urinary protein level and patients'satisfaction to treatment, and the two drugs showed complementary effect yet without causing serious adverse drug reaction, hence this combination therapy is worthy of clinical recommendation.
