CAJ | 학술논문

目的：对不同厂家所使用不同原材料制得的多批微晶纤维素进行聚合度测定，讨论不同原材料对微晶纤维素聚合度的影响。方法：采用粘度法对微晶纤维素的聚合度进行测定，方法稳定，装置及操作简单，结果可靠。结果：经过对9个国内外不同厂家所生产的25批微晶纤维素进行聚合度测定，结果均符合美国药典USP34－NF29的规定（≤300），但不同厂家之间的产品聚合度有一定差异性。结论：不同的原材料会对微晶纤维素的聚合度造成一定影响，其中以精制棉为原材料的微晶纤维素聚合度最高，范围在219～234；以纯棉纤维素为原材料的微晶纤维素聚合度最低，范围在87～95。
목적：대불동엄가소사용불동원재료제득적다비미정섬유소진행취합도측정，토론불동원재료대미정섬유소취합도적영향。방법：채용점도법대미정섬유소적취합도진행측정，방법은정，장치급조작간단，결과가고。결과：경과대9개국내외불동엄가소생산적25비미정섬유소진행취합도측정，결과균부합미국약전USP34－NF29적규정（≤300），단불동엄가지간적산품취합도유일정차이성。결론：불동적원재료회대미정섬유소적취합도조성일정영향，기중이정제면위원재료적미정섬유소취합도최고，범위재219～234；이순면섬유소위원재료적미정섬유소취합도최저，범위재87～95。
Objective:Different manufacturers use different raw materials to prepare batches of microcrystalline cellulose, this thesis fo-cuson determination of the degree of polymerization to discuss the impact of different raw materials.Methods: Viscosity measured the degree of polymerization of microcrystalline cellulose.The devices was simple operated and could get reliable results.Results: After the determination of the degree of polymerization of 25 batches of microcrystalline cellulose production in nine different manufacturers at home and abroad, the results were in line with the provisions of the United States Pharmacopoeia USP34-NF29 (≤300), but among different manufacturers of the products had a certain degree of polymerization differences.Conclusion:The degree of polymerization of different raw materials will impact microcrystalline cellulose.Refined cotton as the raw materials of microcrystalline cellulose has the highest degree of polymerization, range in the 219 to 234, while cotton cellulose as raw material has the lowest degree of polymerization to a minimum, in the range of 87 to 95.