中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2015年
15期
1127-1130
,共4页
李欣%杨丽%张璘洁%付莹%李立敏
李訢%楊麗%張璘潔%付瑩%李立敏
리흔%양려%장린길%부형%리립민
重症肌无力%嗅觉%日常生活活动
重癥肌無力%嗅覺%日常生活活動
중증기무력%후각%일상생활활동
Myasthenia gravis%Smell%Activity of daily living
目的 探讨重症肌无力(MG)患者嗅觉功能及其与临床特征的相关性.方法 利用T&T嗅觉检测法对自2014年3-7月在天津医科大学总医院神经内科确诊的61例重症肌无力患者和32名健康对照进行嗅觉检测,收集MG患者临床信息,利用Spearman相关性分析嗅觉功能与临床特征的相关性.结果 重症肌无力患者嗅觉识别阈为(2.07±1.56),健康对照嗅觉识别阈为(0.31±1.25),二者差异具有统计学意义(t=5.50,P＜0.01),Spearman相关分析显示重症肌无力患者嗅觉水平与病程(r =0.348,P=1.006)、疾病严重程度定量(QMG)评分(r=0.393,P=0.025)、每日生存活动等级(ADL)评分(r=0.421,P=0.01)和累计服用溴吡斯的明的时间(r=0.295,P=0.025)呈正相关;与累计服用泼尼松时间(r=0.084,P=0.053)、服用免疫抑制剂时间(r=0.153,P=0.251)无相关性.结论 重症肌无力患者存在嗅觉功能下降,提示重症肌无力患者可能存在不可忽视的非运动功能损害.
目的 探討重癥肌無力(MG)患者嗅覺功能及其與臨床特徵的相關性.方法 利用T&T嗅覺檢測法對自2014年3-7月在天津醫科大學總醫院神經內科確診的61例重癥肌無力患者和32名健康對照進行嗅覺檢測,收集MG患者臨床信息,利用Spearman相關性分析嗅覺功能與臨床特徵的相關性.結果 重癥肌無力患者嗅覺識彆閾為(2.07±1.56),健康對照嗅覺識彆閾為(0.31±1.25),二者差異具有統計學意義(t=5.50,P＜0.01),Spearman相關分析顯示重癥肌無力患者嗅覺水平與病程(r =0.348,P=1.006)、疾病嚴重程度定量(QMG)評分(r=0.393,P=0.025)、每日生存活動等級(ADL)評分(r=0.421,P=0.01)和纍計服用溴吡斯的明的時間(r=0.295,P=0.025)呈正相關;與纍計服用潑尼鬆時間(r=0.084,P=0.053)、服用免疫抑製劑時間(r=0.153,P=0.251)無相關性.結論 重癥肌無力患者存在嗅覺功能下降,提示重癥肌無力患者可能存在不可忽視的非運動功能損害.
목적 탐토중증기무력(MG)환자후각공능급기여림상특정적상관성.방법 이용T&T후각검측법대자2014년3-7월재천진의과대학총의원신경내과학진적61례중증기무력환자화32명건강대조진행후각검측,수집MG환자림상신식,이용Spearman상관성분석후각공능여림상특정적상관성.결과 중증기무력환자후각식별역위(2.07±1.56),건강대조후각식별역위(0.31±1.25),이자차이구유통계학의의(t=5.50,P＜0.01),Spearman상관분석현시중증기무력환자후각수평여병정(r =0.348,P=1.006)、질병엄중정도정량(QMG)평분(r=0.393,P=0.025)、매일생존활동등급(ADL)평분(r=0.421,P=0.01)화루계복용추필사적명적시간(r=0.295,P=0.025)정정상관;여루계복용발니송시간(r=0.084,P=0.053)、복용면역억제제시간(r=0.153,P=0.251)무상관성.결론 중증기무력환자존재후각공능하강,제시중증기무력환자가능존재불가홀시적비운동공능손해.
Objective To explore the olfactory function of patients with myasthenia gravis (MG) and analyze the correlation between olfactory dysfunction and clinical characteristics.Methods A total of 61 MG patients from March to July 2014 and 32 healthy controls (HC) received T&T olfactometer test.Their clinical data were collected.And the relationship of T&T score and clinical characteristics were analyzed.Results The identification threshold of T&T olfactometer test was (2.07 ± 1.56) versus (0.31 ±1.25) for healthy controls.MG patients had a worse performance on olfaction test than healthy controls (t =5.50,P ＜ 0.01).By Spearman' s analysis,disease course (r =1.348,P =0.006),QMG scores (r =0.393,P =0.025),ADL scores (r =0.421,P =0.01) and dosing time of pyridostigmine (r =0.295,P=0.025) were positively correlated with T&T scores.However,the dosing times of prednisone (r =0.084,P =0.053) or immunodepressants (r =0.153,P =0.251) were not correlated with T&T scores.Conclusion MG patients have poor olfactory sensation.And a potential involvement of non-motor system shall attract the attention of neurologists.
