中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
2期
196-198,297
,共4页
缺血缺氧性脑病%新生儿%危险因素%Logistic回归分析
缺血缺氧性腦病%新生兒%危險因素%Logistic迴歸分析
결혈결양성뇌병%신생인%위험인소%Logistic회귀분석
hypoxic ischemic encephalopathy ( HIE)%neonates%risk factors%Logistic regression analysis
目的:探讨新生儿缺血缺氧性脑病( HIE)发生的相关危险因素。方法回顾性分析绍兴市上虞妇幼保健院2008年1月至2013年1月收治的350例HIE患儿临床资料,另选取同期顺产的200例非HIE高危新生儿作为对照组,应用单因素分析和Logistic回归分析筛选HIE发生的相关危险因素。结果多因素Logistic回归显示分娩前因素只有妊娠期糖尿病与HIE相关(RR=1.43,95%CI:1.08~2.12,P<0.05),其他HIE独立预测因素均为分娩期因素,即羊水粪染、肩先露、脐带绕颈、产程延长、胎心监护异常、器械助产、急诊剖宫产、1min Apgar<3分和5min Apgar<5分(RR值分别为1.97、6.31、2.26、1.84、2.41、1.91、1.21、17.48和20.07,95%CI分别为1.38~3.67、3.44~12.42、1.52~5.20、1.09~4.65、1.14~5.96、1.24~4.77、1.04~2.39、8.21~174.26和7.26~164.28,均P<0.05)。结论新生儿HIE与母体、胎儿等多种因素相关,其中分娩期是关键,其他因素通过影响分娩期因素起作用。
目的:探討新生兒缺血缺氧性腦病( HIE)髮生的相關危險因素。方法迴顧性分析紹興市上虞婦幼保健院2008年1月至2013年1月收治的350例HIE患兒臨床資料,另選取同期順產的200例非HIE高危新生兒作為對照組,應用單因素分析和Logistic迴歸分析篩選HIE髮生的相關危險因素。結果多因素Logistic迴歸顯示分娩前因素隻有妊娠期糖尿病與HIE相關(RR=1.43,95%CI:1.08~2.12,P<0.05),其他HIE獨立預測因素均為分娩期因素,即羊水糞染、肩先露、臍帶繞頸、產程延長、胎心鑑護異常、器械助產、急診剖宮產、1min Apgar<3分和5min Apgar<5分(RR值分彆為1.97、6.31、2.26、1.84、2.41、1.91、1.21、17.48和20.07,95%CI分彆為1.38~3.67、3.44~12.42、1.52~5.20、1.09~4.65、1.14~5.96、1.24~4.77、1.04~2.39、8.21~174.26和7.26~164.28,均P<0.05)。結論新生兒HIE與母體、胎兒等多種因素相關,其中分娩期是關鍵,其他因素通過影響分娩期因素起作用。
목적:탐토신생인결혈결양성뇌병( HIE)발생적상관위험인소。방법회고성분석소흥시상우부유보건원2008년1월지2013년1월수치적350례HIE환인림상자료,령선취동기순산적200례비HIE고위신생인작위대조조,응용단인소분석화Logistic회귀분석사선HIE발생적상관위험인소。결과다인소Logistic회귀현시분면전인소지유임신기당뇨병여HIE상관(RR=1.43,95%CI:1.08~2.12,P<0.05),기타HIE독립예측인소균위분면기인소,즉양수분염、견선로、제대요경、산정연장、태심감호이상、기계조산、급진부궁산、1min Apgar<3분화5min Apgar<5분(RR치분별위1.97、6.31、2.26、1.84、2.41、1.91、1.21、17.48화20.07,95%CI분별위1.38~3.67、3.44~12.42、1.52~5.20、1.09~4.65、1.14~5.96、1.24~4.77、1.04~2.39、8.21~174.26화7.26~164.28,균P<0.05)。결론신생인HIE여모체、태인등다충인소상관,기중분면기시관건,기타인소통과영향분면기인소기작용。
Objective To investigate the relevant risk factors of hypoxic ischemia encephalopathy (HIE).Methods Retrospective study was conducted on clinical data of 350 neonates with HIE treated in Maternity and Child Care Hospital of Shangyu District during the period of January 2008 to January 2013.Another 200 neonates without high risk of HIE were selected as control group.Risk factors of HIE were analyzed and screened by single factor analysis and Logistic regression analysis.Results Univariate Logistic analysis showed that only gestational diabetes was correlated with HIE before delivery (RR=1.43,95%CI:1.08 -2.12,P<0.05), and that other independent predictive factors were intrapartum complications, including meconium -stained amniotic fluid, shoulder dystocia, tight nuchal cord, prolonged labor, abnormal fetal heart rate, instrumental delivery, emergency cesarean section, 1min Apgar<3 and 5min Apgar<5 ( RR value was 1.97, 6.31, 2.26, 1.84, 2.41, 1.91, 1.21, 17.48 and 20.07,95%CI:1.38-3.67, 3.44-12.42, 1.52-5.20, 1.09-4.65,1.14-5.96,1.24-4.77,1.04-2.39,8.21-174.26 and 7.26-164.28, respectively, all P<0.05).Conclusion Maternal, fetal and other factors are correlated with neonatal HIE.Delivery is the key, and other factors play a role by influencing intrapartum complications.