中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
2期
284-286
,共3页
血小板计数%小儿肺炎%炎症反应%临床%应用价值
血小闆計數%小兒肺炎%炎癥反應%臨床%應用價值
혈소판계수%소인폐염%염증반응%림상%응용개치
platelet count%pneumonia in children%inflammatory reaction%clinics%application value
目的:探讨血小板计数对评估小儿肺炎炎症反应及病情严重程度的应用价值和意义。方法选取绍兴市上虞区妇幼保健院2013年6月至2014年8月收治的重症肺炎80例患儿作为研究对象,对患儿入院第1天、第3天及第5天的血小板数进行回顾性分析,同时分析患儿急性肺损伤(ALI)、急性呼吸窘迫综合征(ARDS)与多器官功能障碍综合征(MODS)的发生率和病死率。综合比较全身炎症反应综合征( SIRS)患儿符合2项、3项及4项SIRS诊断标准的血小板数,ALI、ARDS的发生率和病死率。结果按入院时是否发生SIRS,将患儿分为SIRS组和非SIRS组,两组患儿入院时的血小板数相比,具有显著性差异( t=2.49,P<0.05)。按治疗结局将患儿分为生存组和死亡组,分析两组患儿入院第1天、第3天和第5天的血小板数,生存组的血小板数在入院第1天、第3天和第5天无显著性差异(F=2.8,P>0.05),死亡组则血小板数持续下降,具有统计学意义(F=16.3, P<0.05)。生存组与死亡组ARDS的发生率分别为7.1%(4/56)与45.8%(11/24),具有显著性差异(χ2=33.3,P<0.05)。病死率分别为26.7%(16/60)与10.0%(2/20),具有显著性差异(χ2=3.48,P<0.05)。结论重症肺炎合并SIRS时,血小板的数量会明显升高,这与重症肺炎的病情恶化开始相关,表明血小板可能导致SIRS的启动,所以血小板数量持续下降可作为重症肺炎病情持续恶化的信号之一。
目的:探討血小闆計數對評估小兒肺炎炎癥反應及病情嚴重程度的應用價值和意義。方法選取紹興市上虞區婦幼保健院2013年6月至2014年8月收治的重癥肺炎80例患兒作為研究對象,對患兒入院第1天、第3天及第5天的血小闆數進行迴顧性分析,同時分析患兒急性肺損傷(ALI)、急性呼吸窘迫綜閤徵(ARDS)與多器官功能障礙綜閤徵(MODS)的髮生率和病死率。綜閤比較全身炎癥反應綜閤徵( SIRS)患兒符閤2項、3項及4項SIRS診斷標準的血小闆數,ALI、ARDS的髮生率和病死率。結果按入院時是否髮生SIRS,將患兒分為SIRS組和非SIRS組,兩組患兒入院時的血小闆數相比,具有顯著性差異( t=2.49,P<0.05)。按治療結跼將患兒分為生存組和死亡組,分析兩組患兒入院第1天、第3天和第5天的血小闆數,生存組的血小闆數在入院第1天、第3天和第5天無顯著性差異(F=2.8,P>0.05),死亡組則血小闆數持續下降,具有統計學意義(F=16.3, P<0.05)。生存組與死亡組ARDS的髮生率分彆為7.1%(4/56)與45.8%(11/24),具有顯著性差異(χ2=33.3,P<0.05)。病死率分彆為26.7%(16/60)與10.0%(2/20),具有顯著性差異(χ2=3.48,P<0.05)。結論重癥肺炎閤併SIRS時,血小闆的數量會明顯升高,這與重癥肺炎的病情噁化開始相關,錶明血小闆可能導緻SIRS的啟動,所以血小闆數量持續下降可作為重癥肺炎病情持續噁化的信號之一。
목적:탐토혈소판계수대평고소인폐염염증반응급병정엄중정도적응용개치화의의。방법선취소흥시상우구부유보건원2013년6월지2014년8월수치적중증폐염80례환인작위연구대상,대환인입원제1천、제3천급제5천적혈소판수진행회고성분석,동시분석환인급성폐손상(ALI)、급성호흡군박종합정(ARDS)여다기관공능장애종합정(MODS)적발생솔화병사솔。종합비교전신염증반응종합정( SIRS)환인부합2항、3항급4항SIRS진단표준적혈소판수,ALI、ARDS적발생솔화병사솔。결과안입원시시부발생SIRS,장환인분위SIRS조화비SIRS조,량조환인입원시적혈소판수상비,구유현저성차이( t=2.49,P<0.05)。안치료결국장환인분위생존조화사망조,분석량조환인입원제1천、제3천화제5천적혈소판수,생존조적혈소판수재입원제1천、제3천화제5천무현저성차이(F=2.8,P>0.05),사망조칙혈소판수지속하강,구유통계학의의(F=16.3, P<0.05)。생존조여사망조ARDS적발생솔분별위7.1%(4/56)여45.8%(11/24),구유현저성차이(χ2=33.3,P<0.05)。병사솔분별위26.7%(16/60)여10.0%(2/20),구유현저성차이(χ2=3.48,P<0.05)。결론중증폐염합병SIRS시,혈소판적수량회명현승고,저여중증폐염적병정악화개시상관,표명혈소판가능도치SIRS적계동,소이혈소판수량지속하강가작위중증폐염병정지속악화적신호지일。
Objective To investigate the application and value of platelet count in judging pneumonia inflammatory reaction and the severity of disease in children.Methods The study recruited 80 children of severe pneumonia hospitalized in Shaoxing City Shangyu District Maternal and Child Health Hospital during the period of June 2013 to August 2014.Platelet number was retrospectively analyzed at the first, third and fifth day after admission.The incidence of ALI, ARDS and MODS and mortality were analyzed.Platelet number of SIRS children meeting two, three and four diagnostic criteria, the incidence of ALI and ARDS as well as mortality were analyzed.Results Patients were divided into SIRS group and non-SIRS group according to whether they had SIRS at admission.The platelet number at admission was significantly different between two groups (t=2.49,P<0.05).Patients were divided into survival group and death group, and their platelet number was analyzed at the first, third and fifth day after admission.There was no significant difference in platelet number at the first, third and fifth day after admission in survival group (F=2.8,P>0.05), but the platelet number reduced continuously with statistical significance (F=16.3, P<0.05).The incidence of ARDS in survival group (7.1%, 4/56) and death group (45.8%, 11/24) was significantly different (χ2 =33.3,P<0.05), and the mortality was 26.7%(16/60) and 10.0%(2/20), respectively with significant difference (χ2 =3.48, P <0.05).Conclusion The number of platelets will significantly increase at severe pneumonia complicated with SIRS, which is correlated with the beginning of deterioration of severe pneumonia.It may suggest that platelets may lead to SIRS start, so the decreasing of platelets number can be used as one signal of sustained worsening of severe pneumonia.