中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
2期
261-263
,共3页
中枢性性早熟%促性腺激素释放激素类似物%生长激素%临床研究
中樞性性早熟%促性腺激素釋放激素類似物%生長激素%臨床研究
중추성성조숙%촉성선격소석방격소유사물%생장격소%림상연구
central precocious puberty ( CPP)%GnRHa%rhGH%clinical research
目的:评价促性腺激素释放激素类似物( GnRHa)和生长激素( rhGH)联合用药与单纯使用GnRHa治疗大骨龄特发性中枢性性早熟( CPP)的疗效。方法收集2010年1月至2013年1月期间在嘉兴市第一医院就诊的中枢性性早熟女童65例。根据用药不同,将纳入患者分为试验组( GnRHa和rhGH联用)32例和对照组( GnRHa单用)33例,两组患儿年龄、骨龄及身高等相比,差异无统计学意义。观察治疗后身高、骨龄和预测成年身高( PAH)。结果治疗后试验组身高和预测成年身高均高于对照组,差异均有统计学差异(t值分别为3.009和4.813,均P<0.05),骨龄无统计学差异(t=1.138,P>0.05)。试验组根据实际年龄计算的身高标准差积分(Ht-SDSCA)较治疗前无明显改变;而根据骨龄计算的身高标准差分值(Ht-SDSBA)在治疗后的9个月(t=-7.436,P<0.05),12个月(t=-13.663,P<0.01)较治疗前显著增高。结论研究提示,GnRHa和rhGH联合使用比单用GnRHa能更好的改善大骨龄特发性中枢性性早熟患儿的身高以及预测成年身高。
目的:評價促性腺激素釋放激素類似物( GnRHa)和生長激素( rhGH)聯閤用藥與單純使用GnRHa治療大骨齡特髮性中樞性性早熟( CPP)的療效。方法收集2010年1月至2013年1月期間在嘉興市第一醫院就診的中樞性性早熟女童65例。根據用藥不同,將納入患者分為試驗組( GnRHa和rhGH聯用)32例和對照組( GnRHa單用)33例,兩組患兒年齡、骨齡及身高等相比,差異無統計學意義。觀察治療後身高、骨齡和預測成年身高( PAH)。結果治療後試驗組身高和預測成年身高均高于對照組,差異均有統計學差異(t值分彆為3.009和4.813,均P<0.05),骨齡無統計學差異(t=1.138,P>0.05)。試驗組根據實際年齡計算的身高標準差積分(Ht-SDSCA)較治療前無明顯改變;而根據骨齡計算的身高標準差分值(Ht-SDSBA)在治療後的9箇月(t=-7.436,P<0.05),12箇月(t=-13.663,P<0.01)較治療前顯著增高。結論研究提示,GnRHa和rhGH聯閤使用比單用GnRHa能更好的改善大骨齡特髮性中樞性性早熟患兒的身高以及預測成年身高。
목적:평개촉성선격소석방격소유사물( GnRHa)화생장격소( rhGH)연합용약여단순사용GnRHa치료대골령특발성중추성성조숙( CPP)적료효。방법수집2010년1월지2013년1월기간재가흥시제일의원취진적중추성성조숙녀동65례。근거용약불동,장납입환자분위시험조( GnRHa화rhGH련용)32례화대조조( GnRHa단용)33례,량조환인년령、골령급신고등상비,차이무통계학의의。관찰치료후신고、골령화예측성년신고( PAH)。결과치료후시험조신고화예측성년신고균고우대조조,차이균유통계학차이(t치분별위3.009화4.813,균P<0.05),골령무통계학차이(t=1.138,P>0.05)。시험조근거실제년령계산적신고표준차적분(Ht-SDSCA)교치료전무명현개변;이근거골령계산적신고표준차분치(Ht-SDSBA)재치료후적9개월(t=-7.436,P<0.05),12개월(t=-13.663,P<0.01)교치료전현저증고。결론연구제시,GnRHa화rhGH연합사용비단용GnRHa능경호적개선대골령특발성중추성성조숙환인적신고이급예측성년신고。
Objective To observe the curative effect of combined using GnRHa and rhGH in treating big bone age of idiopathic central precocious puberty ( CPP) and that of single GnRHa.Methods Totally 65 girls with CPP treated in Zhejiang Jiaxing First Hospital were selected from January 2010 to January 2013.They were divided into experimental group (combined using of GnRHa and rhGH, n=32) and control group (single GnRHa, n=33).There was no significant difference in age, bone age and height between two groups.The height, bone age and predicted adult height ( PAH) were observed.Results After treatment, height and PAH in the experimental group were higher than those in the control group, and the differences were significant ( t value was 3.009 and 4.813, respectively, both P<0.05).There was no significant difference in bone age (t=1.138,P>0.05).In the experimental group Ht-SDSCA calculated according to actual age was not remarkably different after treatment, but Ht-SDSBA calculated according to bone age was significantly higher at 9 month and 12 month after treatment (t value was -7.436 and -13.663, respectively, both P<0.01).Conclusion Combination therapy with GnRHa and rhGH can significantly improve the height and PAH in girls with big bone age of idiopathic CPP.