中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
2期
280-281,309
,共3页
儿童%川崎病%临床表现%心血管病变%并发症
兒童%川崎病%臨床錶現%心血管病變%併髮癥
인동%천기병%림상표현%심혈관병변%병발증
children%Kawasaki disease%clinical manifestations%cardiovascular disease%complication
目的：分析川崎病住院患儿的临床表现及辅助检查相关指标与心血管系统的并发症之间的关系，为川崎病的治疗提供指导。方法2008年1月至2013年1月温岭巿妇女儿童医院儿科收住的川崎病患儿56例为研究对象，入院后收集患儿的临床资料，查体并行相关辅助检查，对上述指标进行统计学分析。结果①56例川崎病患儿合并心血管系统损害的有34例，占总人数的60．71％。其中心电图异常12例（21．43％），心脏彩超异常31例（55．36％），两者均异常者9例；②多因素Logistic回归分析提示：C－反应蛋白（CRP）OR＝1．786，就诊前发热持续时间（OR＝1．345），血小板计数（PLT）OR＝2．565，与川崎病患儿心血管系统损害均有显著意义（均P＜0．05）。结论川崎病患儿早期发生心血管系统损害的比率高，CRP、就诊前发热持续时间和PLT是心血管系统损害的高危因素，在发病早期应以上因素高度重视。
目的：分析川崎病住院患兒的臨床錶現及輔助檢查相關指標與心血管繫統的併髮癥之間的關繫，為川崎病的治療提供指導。方法2008年1月至2013年1月溫嶺巿婦女兒童醫院兒科收住的川崎病患兒56例為研究對象，入院後收集患兒的臨床資料，查體併行相關輔助檢查，對上述指標進行統計學分析。結果①56例川崎病患兒閤併心血管繫統損害的有34例，佔總人數的60．71％。其中心電圖異常12例（21．43％），心髒綵超異常31例（55．36％），兩者均異常者9例；②多因素Logistic迴歸分析提示：C－反應蛋白（CRP）OR＝1．786，就診前髮熱持續時間（OR＝1．345），血小闆計數（PLT）OR＝2．565，與川崎病患兒心血管繫統損害均有顯著意義（均P＜0．05）。結論川崎病患兒早期髮生心血管繫統損害的比率高，CRP、就診前髮熱持續時間和PLT是心血管繫統損害的高危因素，在髮病早期應以上因素高度重視。
목적：분석천기병주원환인적림상표현급보조검사상관지표여심혈관계통적병발증지간적관계，위천기병적치료제공지도。방법2008년1월지2013년1월온령불부녀인동의원인과수주적천기병환인56례위연구대상，입원후수집환인적림상자료，사체병행상관보조검사，대상술지표진행통계학분석。결과①56례천기병환인합병심혈관계통손해적유34례，점총인수적60．71％。기중심전도이상12례（21．43％），심장채초이상31례（55．36％），량자균이상자9례；②다인소Logistic회귀분석제시：C－반응단백（CRP）OR＝1．786，취진전발열지속시간（OR＝1．345），혈소판계수（PLT）OR＝2．565，여천기병환인심혈관계통손해균유현저의의（균P＜0．05）。결론천기병환인조기발생심혈관계통손해적비솔고，CRP、취진전발열지속시간화PLT시심혈관계통손해적고위인소，재발병조기응이상인소고도중시。
Objective To investigate the clinical manifestations of hospitalized children with Kawasaki disease and the correlation between indexes of auxiliary examination and the complications of cardiovascular system, so as to provide some guidance for treatment of the disease.Methods The study included 56 children with Kawasaki disease hospitalized in pediatric department of Wenling Women and Children’ s Hospital during the period of January 2008 to January 2013.The clinical data of the children were collected.They took physical examination and some auxiliary examinations.All of the indexes were analyzed statistically.Results Totally 34 of 56 cases of Kawasaki disease were complicated with cardiovascular damages, accounting for 60.71%.There were 12 cases (21.43%) with abnormal ECG and 31 cases with abnormal cardiac ultrasonic results (55.36%).Nine cases suffered both.Multivariate Logistic regression analysis showed that CRP (OR=1.786), duration of fever before treatment (OR=1.345) and PLT (OR=2.565) were significantly correlated with cardiovascular damages in children with Kawasaki disease (all P<0.05).Conclusion The incidence of cardiovascular damages on children with Kawasaki disease at early stage is high.CRP, heating duration before treatment and PLT are high-risk factors of cardiovascular damages, therefore, much attention should be paid to the above factors at early stage.
