中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
2期
268-270
,共3页
低分子肝素%新生儿%脓毒症%弥散性血管内凝血
低分子肝素%新生兒%膿毒癥%瀰散性血管內凝血
저분자간소%신생인%농독증%미산성혈관내응혈
low molecular weight heparin(LMWH)%newborns%sepsis%disseminated intravascular coagulation(DIC)
目的：探讨低分子肝素治疗新生儿脓毒症并弥散性血管内凝血（ DIC）的临床疗效及应用价值。方法选择宁波大学医学院附属医院治疗的新生儿脓毒症并DIC患儿84例，随机分为观察组和对照组各42例。对照组给予西医常规治疗，观察组在对照组基础上联合低分子肝素治疗，观察两组患儿的临床疗效。结果观察组新生儿DIC指标恢复正常时间、出血停止时间、肝素使用时间、重症监护室（ ICU）住院时间与对照组相比，差异均有统计学意义（ t值分别为10．1390、12．6781、9．9306和15．4051，均P＜0．001）。观察组治疗后C－反应蛋白、降钙素原与对照组治疗后比较，差异均具有统计学意义（ t值分别为6．5706和5．0614，均P＜0．001）。观察组治疗后部分凝血酶原时间、D－二聚体、血小板计数与对照组相比，差异均具有统计学意义（ t值分别为15．1883、15．3153和7．6557，均P＜0．001）。结论低分子肝素可以有效改善新生儿脓毒症合并弥散性血管内凝血患儿凝血功能，减轻体内炎症反应，缩短ICU住院时间，值得在临床大力推广使用。
目的：探討低分子肝素治療新生兒膿毒癥併瀰散性血管內凝血（ DIC）的臨床療效及應用價值。方法選擇寧波大學醫學院附屬醫院治療的新生兒膿毒癥併DIC患兒84例，隨機分為觀察組和對照組各42例。對照組給予西醫常規治療，觀察組在對照組基礎上聯閤低分子肝素治療，觀察兩組患兒的臨床療效。結果觀察組新生兒DIC指標恢複正常時間、齣血停止時間、肝素使用時間、重癥鑑護室（ ICU）住院時間與對照組相比，差異均有統計學意義（ t值分彆為10．1390、12．6781、9．9306和15．4051，均P＜0．001）。觀察組治療後C－反應蛋白、降鈣素原與對照組治療後比較，差異均具有統計學意義（ t值分彆為6．5706和5．0614，均P＜0．001）。觀察組治療後部分凝血酶原時間、D－二聚體、血小闆計數與對照組相比，差異均具有統計學意義（ t值分彆為15．1883、15．3153和7．6557，均P＜0．001）。結論低分子肝素可以有效改善新生兒膿毒癥閤併瀰散性血管內凝血患兒凝血功能，減輕體內炎癥反應，縮短ICU住院時間，值得在臨床大力推廣使用。
목적：탐토저분자간소치료신생인농독증병미산성혈관내응혈（ DIC）적림상료효급응용개치。방법선택저파대학의학원부속의원치료적신생인농독증병DIC환인84례，수궤분위관찰조화대조조각42례。대조조급여서의상규치료，관찰조재대조조기출상연합저분자간소치료，관찰량조환인적림상료효。결과관찰조신생인DIC지표회복정상시간、출혈정지시간、간소사용시간、중증감호실（ ICU）주원시간여대조조상비，차이균유통계학의의（ t치분별위10．1390、12．6781、9．9306화15．4051，균P＜0．001）。관찰조치료후C－반응단백、강개소원여대조조치료후비교，차이균구유통계학의의（ t치분별위6．5706화5．0614，균P＜0．001）。관찰조치료후부분응혈매원시간、D－이취체、혈소판계수여대조조상비，차이균구유통계학의의（ t치분별위15．1883、15．3153화7．6557，균P＜0．001）。결론저분자간소가이유효개선신생인농독증합병미산성혈관내응혈환인응혈공능，감경체내염증반응，축단ICU주원시간，치득재림상대력추엄사용。
Objective To investigate the clinical efficacy and value of low molecular weight heparin (LMWH) on treatment of neonatal sepsis complicated with disseminated intravascular coagulation ( DIC) .Methods Eighty-four cases of neonatal sepsis complicated with DIC treated in Affiliated Hospital of Medical College of Ningbo University were randomly divided into control group and observation group with 42 cases in each.The control group received conventional treatment, while the observation group was given LMWH therapy additionally. The clinical efficacy of two groups was observed.Results After treatment, there were significant differences in time for neonatal DIC index returning to normal, bleeding stop time, heparin using time and duration in ICU between two groups ( t value was 10.1390, 12.6781, 9.9306 and 15.4051, respectively, all P<0.001).Compared with the control group, CRP and PCT were significantly different in the observation group (t value was 6.5706 and 5.0614, respectively, both P<0.001).Partial prothrombin time, D-dimer concentration and platelet count were remarkably different between two groups (t value was 15.1883, 15.3153 and 7.6557, respectively, all P<0.001). Conclusion LMWH in the treatment of neonatal sepsis with DIC can improve coagulation function effectively, lessen inflammatory reaction and reduce ICU hospitalization length.It is worthy of clinical application.
