世界中西医结合杂志
世界中西醫結閤雜誌
세계중서의결합잡지
WORLD JOURNAL OF TRADITIONAL CHINESE AND WESTERN MEDICINE
2015年
4期
493-495,498
,共4页
豨莶草%苍耳子%急性毒性%毒性界定%血液流变学
豨薟草%蒼耳子%急性毒性%毒性界定%血液流變學
희렴초%창이자%급성독성%독성계정%혈액류변학
Siegesbeckiae%Cocklebur%Acute toxicity%Toxicity defined%Blood rheology
目的：以药典记载的菊科、辛味药苍耳子（有毒）与豨莶草（无毒）进行急性毒性和药效实验比较研究，确定两者的毒性-药效剂量关系，为药典中药毒性界定和分级存在的不足提供实验依据，为临床安全合理用药提供注意事项。方法分别制备豨莶草和苍耳子水煎剂，采用小鼠一次性灌胃观察毒性，计算半数致死量（ LD50）；复制大鼠急性血瘀模型，观察两药的药效作用。结果豨莶草半数致死量LD50＝18.0 g/kg，苍耳子半数致死量LD50＝18.6 g/kg。豨莶草及苍耳子组均能降低全血黏度及血浆黏度，前者毒性-药效剂量关系比为85倍，后者毒性-药效剂量关系比为75倍。结论豨莶草与苍耳子半数致死量及毒性-药效剂量关系比较无统计学意义，提示药典对有毒药物及无毒药物的界定和分级存在不足，该实验对药典有毒药物及无毒药物的界定提出质疑，也为临床安全合理用药提供注意事项。
目的：以藥典記載的菊科、辛味藥蒼耳子（有毒）與豨薟草（無毒）進行急性毒性和藥效實驗比較研究，確定兩者的毒性-藥效劑量關繫，為藥典中藥毒性界定和分級存在的不足提供實驗依據，為臨床安全閤理用藥提供註意事項。方法分彆製備豨薟草和蒼耳子水煎劑，採用小鼠一次性灌胃觀察毒性，計算半數緻死量（ LD50）；複製大鼠急性血瘀模型，觀察兩藥的藥效作用。結果豨薟草半數緻死量LD50＝18.0 g/kg，蒼耳子半數緻死量LD50＝18.6 g/kg。豨薟草及蒼耳子組均能降低全血黏度及血漿黏度，前者毒性-藥效劑量關繫比為85倍，後者毒性-藥效劑量關繫比為75倍。結論豨薟草與蒼耳子半數緻死量及毒性-藥效劑量關繫比較無統計學意義，提示藥典對有毒藥物及無毒藥物的界定和分級存在不足，該實驗對藥典有毒藥物及無毒藥物的界定提齣質疑，也為臨床安全閤理用藥提供註意事項。
목적：이약전기재적국과、신미약창이자（유독）여희렴초（무독）진행급성독성화약효실험비교연구，학정량자적독성-약효제량관계，위약전중약독성계정화분급존재적불족제공실험의거，위림상안전합리용약제공주의사항。방법분별제비희렴초화창이자수전제，채용소서일차성관위관찰독성，계산반수치사량（ LD50）；복제대서급성혈어모형，관찰량약적약효작용。결과희렴초반수치사량LD50＝18.0 g/kg，창이자반수치사량LD50＝18.6 g/kg。희렴초급창이자조균능강저전혈점도급혈장점도，전자독성-약효제량관계비위85배，후자독성-약효제량관계비위75배。결론희렴초여창이자반수치사량급독성-약효제량관계비교무통계학의의，제시약전대유독약물급무독약물적계정화분급존재불족，해실험대약전유독약물급무독약물적계정제출질의，야위림상안전합리용약제공주의사항。
Objective To study the toxicity-dosage relation of Siegesbeckiae and Cocklebur through acute toxicity test and efficacy experiment. To provide experimental basis for the toxicity definition of traditional Chinese medicine( TCM)and to provide considerations for clinical safety drug using. Methods Prepare water decoction of Siegesbeckiae and Cocklebur respectively. Lavaging for micedisposable to observe the toxicity and calculate the median lethal dose. Copying acute blood stasis model in rats to observe the efficacy of the two drugs. Results Median lethal dose of Siegesbeckiae is 18. 0 g/kg. Median lethal dose of Cocklebur is 18. 6 g/kg. Siegesbeckiae and Cocklebur could decrease whole blood viscosity and plasma viscosity. Toxic-effective dose of Siegesbeckiae is 85 times and 75 times for Cocklebur. Conclusion There was no significant difference between Siegesbeckiae and Cocklebur in median lethal dose and toxic-effective dose. The Phar-macopoeia of TCM has shortcomings in the definition and classification of toxic drugs and nonpoisonous drugs. The experiment questioned the definition of toxic drugs and nonpoisonous drugs,and provided consider-ations for clinical safety drug using.
