CAJ | 학술논문

目的：比较卡培他滨+多西他赛、卡培他滨+长春瑞滨治疗乳腺癌肝转移的疗效及安全性。方法以本院2012年1月~2014年12月收治的50例乳腺癌肝转移患者为研究对象，根据不同化疗方案将其分为A、B组。A组采取卡培他滨+多西他赛治疗，B组给予卡培他滨+长春瑞滨治疗，比较两组临床疗效及不良反应发生情况。结果 A组治疗有效率、不良反应发生率分别为72.0%、24.0%，与B组的68.0%、32.0%比较，差异无统计学意义(P>0.05)。结论卡培他滨+多西他赛、卡培他滨+长春瑞滨治疗乳腺癌肝转移的效果及不良反应无明显差异，但临床建议优先选择卡培他滨+多西他赛化疗方案。
목적：비교잡배타빈+다서타새、잡배타빈+장춘서빈치료유선암간전이적료효급안전성。방법이본원2012년1월~2014년12월수치적50례유선암간전이환자위연구대상，근거불동화료방안장기분위A、B조。A조채취잡배타빈+다서타새치료，B조급여잡배타빈+장춘서빈치료，비교량조림상료효급불량반응발생정황。결과 A조치료유효솔、불량반응발생솔분별위72.0%、24.0%，여B조적68.0%、32.0%비교，차이무통계학의의(P>0.05)。결론잡배타빈+다서타새、잡배타빈+장춘서빈치료유선암간전이적효과급불량반응무명현차이，단림상건의우선선택잡배타빈+다서타새화료방안。
Objective To compare the efficacy and safety of capecitabine with docetaxel and capecitabine with vinorel-bine in the treatment of breast cancer liver metastasis. Methods 50 patients with breast cancer liver metastasis from January 2012 to December 2014 in our hospital were selected as research objects,according to different chemotherapy regimens were divided into group A and group B.Capecitabine with docetaxel was used in group A,capecitabine with vinorelbine was applied in group B.The clinical curative effect and adverse reaction between the two groups was com-pared. Results The total effective rate and incidence of adverse reactions in group A was 72.0% and 24.0% respec-tively,while in group B,that was 68.0% and 32.0% in turn,the difference was not significant (P>0.05). Conclusion There is no significant difference in curative effect or adverse reaction by capecitabine with docetaxel or capecitabine with vinorelbine in treating breast cancer liver metastasis,but the chemotherapy regimen of capecitabine with docetaxel is preferred by physician’s suggestion in clinic.