中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
2期
188-190,233
,共4页
儿童%手足口病%流行病学特征%回顾性分析
兒童%手足口病%流行病學特徵%迴顧性分析
인동%수족구병%류행병학특정%회고성분석
children%hand-foot-mouth disease%epidemic characteristics%retrospective analysis
目的：探讨武汉市阳逻地区2008至2012年儿童手足口病流行病学和病原学特征，为手足口病的防治提供科学依据。方法收集2008至2012年在湖北省中山医院阳逻院区儿科治疗的874例手足口病病案资料，对其进行描述性流行病学方法分析。结果在874例手足口病例中，男584例，女290例。2008至2011年武汉阳逻地区手足口病发病人数呈逐年上升趋势（χ2＝36．54，P＜0．001），2012年有所下降。发病高峰集中在4～9月份；发病年龄以5岁以下幼儿为主；发病人群以散居儿童或幼托儿童为主。2011年报告的病重率明显高于其它年份（χ2＝16．92，P＜0．001）。男性儿童发病率高于女性儿童，每年性别比平均维持在1．50：1以上。普通病例为肠道病毒71型（EV71）和柯萨奇病毒A16型（coxA16）共同主导流行。重症和死亡病例以EV71为流行优势株。结论武汉市阳逻地区手足口病流行有明显季节性、人群性以及地区性，引起手足口病普通病例流行的病原体主要为EV71和CoxA16，且不同年份流行优势株有所不同，重症病例和死亡病例的流行优势毒株均为EV71。
目的：探討武漢市暘邏地區2008至2012年兒童手足口病流行病學和病原學特徵，為手足口病的防治提供科學依據。方法收集2008至2012年在湖北省中山醫院暘邏院區兒科治療的874例手足口病病案資料，對其進行描述性流行病學方法分析。結果在874例手足口病例中，男584例，女290例。2008至2011年武漢暘邏地區手足口病髮病人數呈逐年上升趨勢（χ2＝36．54，P＜0．001），2012年有所下降。髮病高峰集中在4～9月份；髮病年齡以5歲以下幼兒為主；髮病人群以散居兒童或幼託兒童為主。2011年報告的病重率明顯高于其它年份（χ2＝16．92，P＜0．001）。男性兒童髮病率高于女性兒童，每年性彆比平均維持在1．50：1以上。普通病例為腸道病毒71型（EV71）和柯薩奇病毒A16型（coxA16）共同主導流行。重癥和死亡病例以EV71為流行優勢株。結論武漢市暘邏地區手足口病流行有明顯季節性、人群性以及地區性，引起手足口病普通病例流行的病原體主要為EV71和CoxA16，且不同年份流行優勢株有所不同，重癥病例和死亡病例的流行優勢毒株均為EV71。
목적：탐토무한시양라지구2008지2012년인동수족구병류행병학화병원학특정，위수족구병적방치제공과학의거。방법수집2008지2012년재호북성중산의원양라원구인과치료적874례수족구병병안자료，대기진행묘술성류행병학방법분석。결과재874례수족구병례중，남584례，녀290례。2008지2011년무한양라지구수족구병발병인수정축년상승추세（χ2＝36．54，P＜0．001），2012년유소하강。발병고봉집중재4～9월빈；발병년령이5세이하유인위주；발병인군이산거인동혹유탁인동위주。2011년보고적병중솔명현고우기타년빈（χ2＝16．92，P＜0．001）。남성인동발병솔고우녀성인동，매년성별비평균유지재1．50：1이상。보통병례위장도병독71형（EV71）화가살기병독A16형（coxA16）공동주도류행。중증화사망병례이EV71위류행우세주。결론무한시양라지구수족구병류행유명현계절성、인군성이급지구성，인기수족구병보통병례류행적병원체주요위EV71화CoxA16，차불동년빈류행우세주유소불동，중증병례화사망병례적류행우세독주균위EV71。
Objective To explore the epidemic and virological characteristics of hand-foot-mouth disease among children during 2008 to 2012 in Yangluo of Wuhan City, so as to provide scientific basis for prevention and control of the disease.Methods The clinical data of 874 cases of hand-foot-mouth disease treated in pediatric department of Yangluo School District of Hubei Zhongshan Hospital were collected during the period of 2008 to 2012, and they were analyzed with descriptive epidemiological methods.Results Among 874 cases, there were 584 male cases and 290 female cases.The number of cases showed a rising trend during 2008 to 2011 (χ2 =36.54,P<0.001), but it declined in 2012.The peak onset time was April to September, and onset age gave priority to under five years old.The crowd gave priority to scattered children or preschool children.The incidence of severe disease was significantly higher in 2011 (χ2 =16.92,P<0.001) .The incidence of the disease was higher in boys than girls, and the gender ratio remained over 1.50:1.Enterovirus 71 (EV71) and coxsackie virus A16 (CoxA16) dominated common cases, while the severe cases and death cases were mainly infected with EV71.Conclusion Hand-foot-mouth disease has obvious season, population and region characteristics in Yangluo of Wuhan.EV71 and CoxA16 are the main pathogens of common cases, and dominate strains are different in different year.Both severe cases and death cases are mainly infected with EV71.
