CAJ | 학술논문

目的：探讨肺炎支原体感染患儿血浆D－二聚体含量在肺炎支原体感染过程中的变化及临床意义。方法将来自深圳市宝安妇幼保健院2012年7月至2014年3月住院期间的176例肺炎支原体感染患儿依其病程分为感染组（176例）和治愈组（60例），同时选取70例正常儿童作为对照组，分别测定其血浆D－二聚体及血清肺炎支原体抗体，并对其进行比较分析。结果肺炎支原体感染组患儿血浆D－二聚体水平较治愈组和对照组显著升高（t值分别为4．33和5．11，均P＜0．05）、肺炎支原体感染期间（肺炎支原体抗体滴度水平在1：320及以上者53例，滴度在1：160者65例，滴度1：80的58例）不同抗体水平的患儿血浆D－二聚体水平均无明显差异（t值分别为0．64、0．48和1．40，均P＞0．05）。结论肺炎支原体感染患儿体内存在着凝血、纤溶活性的异常，D－二聚体水平在感染期明显升高。
목적：탐토폐염지원체감염환인혈장D－이취체함량재폐염지원체감염과정중적변화급림상의의。방법장래자심수시보안부유보건원2012년7월지2014년3월주원기간적176례폐염지원체감염환인의기병정분위감염조（176례）화치유조（60례），동시선취70례정상인동작위대조조，분별측정기혈장D－이취체급혈청폐염지원체항체，병대기진행비교분석。결과폐염지원체감염조환인혈장D－이취체수평교치유조화대조조현저승고（t치분별위4．33화5．11，균P＜0．05）、폐염지원체감염기간（폐염지원체항체적도수평재1：320급이상자53례，적도재1：160자65례，적도1：80적58례）불동항체수평적환인혈장D－이취체수평균무명현차이（t치분별위0．64、0．48화1．40，균P＞0．05）。결론폐염지원체감염환인체내존재착응혈、섬용활성적이상，D－이취체수평재감염기명현승고。
Objective To investigate the changes in infection period and significance of plasma D-dimer levels in mycoplasma pneumoniae infected children.Methods From July 2012 to March 2014 plasma D-dimer and mycoplasma pneumoniae antibodies in serum of 176 cases of mycoplasma pneumonia in infection group admitted in Maternal and Child Health Care Hospital of Baoan District, cure group (n=60) and control group ( n=70) were measured, and comparison analysis was conducted.Results Mycoplasma pneumoniae infection group has significantly higher level of plasma D-dimer than the cure group and the control group (t value was 4.33 and 5.11, respectively, both P<0.05).During the mycoplasma pneumoniae infection period there was no significant difference in D-dimer level among cases with different antibody levels (53 cases with titer of 1:320 or more, 65 cases with titer of 1:160, 58 cases with titer of 1:80) (t value was 0.64, 0.48 and 1.40, respectively, all P >0.05).Conclusion In vivo coagulation and fibrinolytic activity abnormalities exist in children with mycoplasma pneumoniae infection, and their D-dimer levels elevate significantly in infection period.