CAJ | 학술논문

目的：比较中药祛湿霜和丁酸氢化可的松乳膏治疗儿童湿疹的疗效和安全性。方法根据随机数据表法，收回有效病例96例，其中祛湿霜组（ A组）51例，丁酸氢化可的松乳膏组（ B组）45例，两组均局部涂药，每日2次；治疗后3 d、7 d和14 d，根据湿疹皮损EASI评分评判疗效，根据不良事件发生率分析其安全性。结果两组皮损EASI评分随着疗程的增加逐渐降低，表明两组疗法治疗湿疹均有效，并随疗程增加，EASI积分改善也相应下降；在治疗后3 d、7 d和14 d，两组皮损EASI积分相应时间段比较差异无统计学意义（ P﹥0.05），表明两组对皮损EASI积分改善相似。在治疗3 d、7 d和14 d，B组的有效率均优于A组，但差异无统计学意义（P﹥0.05），表明两组的疗效相似。两组不良事件发生率比较差异无统计学意义（P﹥0.05），表明A组与B组的不良事件发生率相似。结论中药祛湿霜是治疗儿童湿疹的安全有效方法。
목적：비교중약거습상화정산경화가적송유고치료인동습진적료효화안전성。방법근거수궤수거표법，수회유효병례96례，기중거습상조（ A조）51례，정산경화가적송유고조（ B조）45례，량조균국부도약，매일2차；치료후3 d、7 d화14 d，근거습진피손EASI평분평판료효，근거불량사건발생솔분석기안전성。결과량조피손EASI평분수착료정적증가축점강저，표명량조요법치료습진균유효，병수료정증가，EASI적분개선야상응하강；재치료후3 d、7 d화14 d，량조피손EASI적분상응시간단비교차이무통계학의의（ P﹥0.05），표명량조대피손EASI적분개선상사。재치료3 d、7 d화14 d，B조적유효솔균우우A조，단차이무통계학의의（P﹥0.05），표명량조적료효상사。량조불량사건발생솔비교차이무통계학의의（P﹥0.05），표명A조여B조적불량사건발생솔상사。결론중약거습상시치료인동습진적안전유효방법。
Objective To compare the efficacy and safety in the treatment of children eczema be-tween Chinese Medicine qushi cream and hydrocortisone butyrate. Methods According to the random data table method,96 effective cases were collected,in which,51 cases were in a qushi cream group( A group)and 45 cases in a hydrocortisone butyrate group( B group). The medicines were applied externally to the affected areas in the two groups,twice a day. In 3,7 and 14 days after treatment,according to the skin lesion,EASI score was used to determine the efficacy. According to the incidence of adverse events,the safety of treatment was analyzed. Results EASI scores of skin lesions were reduced gradually in the treatment of the two groups,indicating the effectiveness on eczema by the therapies in the two groups. The effectiveness was in-creased and EASI scores were declined along with the treatments. In 3,7 and 14 days after treatment,the differences in EASI score were not significant in the corresponding time phases in the two groups(P﹥0. 05), indicating the similarity of the improvements between the two groups. The effective rates in 3,7 and 14 days of treatment in the B group were better than those in the A group,but without significant differences( P﹥0. 05),indicating the efficacy similarity of the two groups. The difference in the adverse events was not signif-icant between the two groups(P﹥0. 05),indicating the similarity of the incidence of the adverse events be-tween the A and B groups. Conclusion Chinese medicine qushi cream is safe and effective in treatment of children eczema.