中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
11期
128-129,132
,共3页
重组人干扰素α1b%病毒性呼吸道感染%临床疗效
重組人榦擾素α1b%病毒性呼吸道感染%臨床療效
중조인간우소α1b%병독성호흡도감염%림상료효
Recombinant interferonα1b%Viral respiratory infection%Curative effects
目的：探讨重组人干扰素α1b治疗小儿病毒性呼吸道感染的效果及安全性。方法以本院2013年6月~2014年6月收治的240例病毒性呼吸道感染患儿为研究对象，随机将其分为A、B、C组，A组行重组人干扰素α1b肌内注射治疗，B组行干扰素雾化治疗，C组给予生理盐水雾化吸入治疗，比较3组的临床疗效、退热时间、全身症状缓解时间、总病程及不良反应情况。结果 A、B组治疗总有效率分别为88.75%、95.00%，均高于C组的76.25%，差异有统计学意义(P<0.05)。 A、B组的退热时间、全身症状缓解时间及总病程明显短于C组(P<0.05)，B组的退热时间、全身症状缓解时间及总病程明显短于A组(P<0.05)。结论重组人干扰素α1b雾化吸入、肌内注射疗效均良好，但雾化吸入总病程更短，值得优先选择。
目的：探討重組人榦擾素α1b治療小兒病毒性呼吸道感染的效果及安全性。方法以本院2013年6月~2014年6月收治的240例病毒性呼吸道感染患兒為研究對象，隨機將其分為A、B、C組，A組行重組人榦擾素α1b肌內註射治療，B組行榦擾素霧化治療，C組給予生理鹽水霧化吸入治療，比較3組的臨床療效、退熱時間、全身癥狀緩解時間、總病程及不良反應情況。結果 A、B組治療總有效率分彆為88.75%、95.00%，均高于C組的76.25%，差異有統計學意義(P<0.05)。 A、B組的退熱時間、全身癥狀緩解時間及總病程明顯短于C組(P<0.05)，B組的退熱時間、全身癥狀緩解時間及總病程明顯短于A組(P<0.05)。結論重組人榦擾素α1b霧化吸入、肌內註射療效均良好，但霧化吸入總病程更短，值得優先選擇。
목적：탐토중조인간우소α1b치료소인병독성호흡도감염적효과급안전성。방법이본원2013년6월~2014년6월수치적240례병독성호흡도감염환인위연구대상，수궤장기분위A、B、C조，A조행중조인간우소α1b기내주사치료，B조행간우소무화치료，C조급여생리염수무화흡입치료，비교3조적림상료효、퇴열시간、전신증상완해시간、총병정급불량반응정황。결과 A、B조치료총유효솔분별위88.75%、95.00%，균고우C조적76.25%，차이유통계학의의(P<0.05)。 A、B조적퇴열시간、전신증상완해시간급총병정명현단우C조(P<0.05)，B조적퇴열시간、전신증상완해시간급총병정명현단우A조(P<0.05)。결론중조인간우소α1b무화흡입、기내주사료효균량호，단무화흡입총병정경단，치득우선선택。
Objective To discuss the effect and safety of recombinant human interferonα1b in the treatment of pediatric viral respiratory infection. Methods 240 children patients with viral respiratory infection who were admitted to our hos-pital from June 2013 to June 2014 were selected as research subjects,and were randomly divided into group A,group B and group C.Group A were given with the treatment of intramuscular injection of recombinant human interferon α1b, group B were given with the treatment of interferon automization,and group C were given with the treatment of aerosol inhalation of normal saline.Clinical curative effects,time of abatement of fever,alleviating time of general symptoms,total course of disease and adverse effects between the three groups was compared. Results The total effective rate of group A and group B was 88.75%and 95.00%respectively,higher than 76.25%of group C,the difference was significant (P<0.05).The time of abatement of fever,alleviation time of general symptoms,the total course of disease in group A and group B was shorter than that in group C (P<0.05),group B was shorter than that in group A (P<0.05). Conclusion Aerosol inhalation of recombinant interferon α1b and intramuscular injection both have favorable curative effects,but the aerosol inhalation has shorter total course of disease,which is worthy of being a preference option.
