CAJ | 학술논문

目的：探讨依达拉奉联合丹红注射液治疗急性心肌梗死后缺血/再灌注损伤的临床效果。方法选取本院2011年1月~2014年10月收治的60例ST段抬高AMI(STEMI)患者作为研究对象，随机分为观察组与对照组，各30例。对照组给予抗血小板、调脂、尿激酶静脉溶栓、抗凝、美托洛尔、卡托普利、硝酸酯类等治疗，观察组在对照组的基础上给予依达拉奉、丹红注射液静脉点滴，疗程均为14 d。比较两组的冠状动脉血管再通率、肌酸激酶同工酶(CK-MB)水平、再灌注心律失常等心血管事件发生率。结果两组的血管再通率比较，差异无统计学意义(P>0.05)。观察组的CK-MB峰值较对照组提前。观察组的再灌注心律失常和严重心力衰竭发生率、死亡率显著低于对照组，差异有统计学意义(P<0.05)。结论依达拉奉联合丹红注射液治疗能够降低急性STEMI患者溶栓后缺血/再灌注损伤发生率，并能改善预后。
목적：탐토의체랍봉연합단홍주사액치료급성심기경사후결혈/재관주손상적림상효과。방법선취본원2011년1월~2014년10월수치적60례ST단태고AMI(STEMI)환자작위연구대상，수궤분위관찰조여대조조，각30례。대조조급여항혈소판、조지、뇨격매정맥용전、항응、미탁락이、잡탁보리、초산지류등치료，관찰조재대조조적기출상급여의체랍봉、단홍주사액정맥점적，료정균위14 d。비교량조적관상동맥혈관재통솔、기산격매동공매(CK-MB)수평、재관주심률실상등심혈관사건발생솔。결과량조적혈관재통솔비교，차이무통계학의의(P>0.05)。관찰조적CK-MB봉치교대조조제전。관찰조적재관주심률실상화엄중심력쇠갈발생솔、사망솔현저저우대조조，차이유통계학의의(P<0.05)。결론의체랍봉연합단홍주사액치료능구강저급성STEMI환자용전후결혈/재관주손상발생솔，병능개선예후。
Objective To explore the clinical effect of edaravone combined with Danhong injection in the treatment of ischemia-reperfusion injury after acute myocardial infarction. Methods 60 patients with ST-segment elevation myocar-dial infarction (STEMI) from January 2011 to October 2014 in our hospital were selected and randomly divided into the observation group and the control group,30 cases in each group.The control group was given the treatment of an-tiplatelet treatment,lipid regulation,urokinase thrombolysis,anticoagulation,betaloc,captopril,and nitrate esters,the obser-vation group was treated with edaravone and Danhong injection on the basis of the control group.The course of treat-ment in the two groups lasted 14 days.The recanalization rate of coronary vessels,the level of creatine kinase-MB (CK-MB),the incidence rate of cardiovascular event like reperfusion arrhythmia in two groups was compared respectively. Results There was no statistical difference in vascular reperfusion rate between two groups (P>0.05). The peak value of CK-MB was in advance in the observation group in comparison with that in the control group.The incidence and mor-tality of reperfusion arrhythmia and severe heart failure in the observation group was lower than that in the control group,with significant difference (P<0.05). Conclusion Combination of edaravone and danhong injection can reduce the occurrence rate of ischemia-reperfusion injury after intravenous thrombolysis in patients with STEMI as well as improve the prognosis.